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Each of the AP poll's top five teams are in action Saturday as the first weekend of November arrives with plenty to be sorted out in conference races and the College Football Playoff picture. While the highlight is a noon showdown between No. 3 Penn State and No. 4 Ohio State, the entire day is filled with games that could shake up the national picture.

As the Nittany Lions are hosting the Buckeyes, No. 5 Miami will be taking on a gritty Duke team led by former Hurricanes coach Manny Diaz in what could be a tense spot for one of the nation's last unbeaten teams. Miami quarterback Cam Ward comes into the game as a +300 play to win the Heisman Trophy, according to the DrafKings sports betting app. Top-ranked Oregon is in action during the afternoon as it looks to continue its run of dominance against the reigning national champions in a daunting road venue.

No. 2 Georgia is playing its annual rivalry game with Florida as the Bulldogs seek to avoid a slip-up before challenging contests against ranked foes Ole Miss and Tennessee. In the evening, No. 10 Texas A&M will try and stay hot as it heads to a hostile venue at South Carolina. In the ACC, a pair of top-20 foes square off as SMU hosts Pitt in a game with major implications. 

As Week 10 action arrives, here's a viewer's guide to help you navigate through all of Saturday's games.

Odds via DraftKings. Use DraftKings promo code at DraftKings Sportsbook to get in the game with all the Week 10 action

All times Eastern

The best games

No. 4 Ohio State at No. 3 Penn State -- noon on Fox, fuboTV (try for free): Penn State would essentially eliminate Ohio State from the conference title race and put the Buckeyes' playoff hopes on shaky footing with a win. The temperature on Ohio State coach Ryan Day would get uncomfortably hot, and the national coach of the year candidacy for Penn State's James Franklin would become very real. But the Buckeyes have won seven straight in the series, including three in a row at Beaver Stadium. Ohio State is a +3 betting favorite, according to DraftKings.

Duke at No. 5 Miami -- noon on ABC, fuboTV (try for free): Former Miami coach Manny Diaz returns to Hard Rock Stadium with a formidable Duke team that has already reached bowl eligibility in Diaz's first season. The Hurricanes have survived some close shaves to reach 8-0 as third-year coach Mario Cristobal has finally gotten the 'Canes spinning in his third season. Miami is heavily favored, and this is a can't-lose spot for Cristobal against his predecessor.

No. 1 Oregon at Michigan -- 3:30 p.m. on CBS, CBSSports.com, CBS Sports App (Free), Paramount+ with Showtime: Michigan's offense is still broken, but the Wolverines were able to snap their two-game losing streak last week with a 24-17 victory over rival Michigan State. Finding out a way to beat top-ranked Oregon will be considerably more challenging. The Ducks have looked authoritative in victories since making a major national statement with a 32-31 win over Ohio State on Oct. 12.

Florida vs. No. 2 Georgia -- 3:30 p.m. on ABC, fuboTV (try for free): In its last two games, Florida took Tennessee down to the wire on the road and then crushed Kentucky. Are the Gators starting to find their stride amid a brutally challenging schedule? If so, Georgia better bring its best, because this rivalry showdown could get interesting. The Bulldogs were ruthless defensively in a win at Texas two weeks ago but have been inconsistent on the year.

No. 10 Texas A&M at South Carolina-- 7:30 p.m. on ABC, fuboTV (try for free): Texas A&M has won seven straight, rising to No. 10 nationally and to solo possession of first in the SEC. But the Aggies have quarterback questions as they face a vicious defensive front inside a hostile venue at South Carolina. Can the Gamecocks inject further chaos into the conference by downing A&M just one week after the Aggies' momentous victory against LSU?

No. 18 Pitt at No. 20 SMU -- 8 p.m. on ACC Network, fuboTV (try for free): There are four ACC teams with unblemished conference records entering Week 10. Two of them are squaring off here. Thus, the outcome will have far-reaching implications in the conference title race and the College Football Playoff race. Pitt is coming off a 28-point beatdown of Syracuse fueled by five interceptions from its defense, whereas SMU somehow managed to beat Duke last week, despite committing six turnovers.

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