Manzardo is out of the lineup for Wednesday's game versus the Tigers.

Following his promotion from Triple-A Columbus on Monday, Manzardo started both of the first two games of the series versus Detroit, going 0-for-7 with five strikeouts. He'll begin Wednesday's contest on the bench, with Jose Ramirez getting a day out of the field and serving as Cleveland's DH.

Lowe went 2-for-4 with two walks, a double, two RBI and a run scored in Tuesday's 15-8 win over Oakland.

Lowe, who has yet to have a day off since returning from an oblique injury in mid-April, has reached base safely 15 times in 16 games. The first baseman leads the team with a .429 on-base percentage and possesses a career-high walk rate of 15.7 percent.

Pasquantino went 3-for-5 with an RBI single, a two-run double and a run during Tuesday's 6-5 loss to the Brewers.

Pasquantino gave the Royals the lead in the fifth inning, plating Kyle Isbel and Bobby Witt on a double off Colin Rea. He came around to score in that same inning when Salvador Perez notched a double himself. The outing marked Pasquantino's third game this season driving in at least three runs, moving him up to 21 RBI on the year.

Astros manager Joe Espada said Tuesday that Abreu has "no timetable" to return to the major-league team, Chandler Rome of The Athletic reports.

Abreu was optioned to the rookie-level Astros' Arizona Complex League affiliate last week after slashing just .099/.156/.113 in 77 plate appearances this season. He's been working on getting his swing right and is "doing very well," per Espada, although Abreu hasn't played in any official games yet. The 37-year-old will likely be assigned to a higher minor-league affiliate eventually as he works his way back to the big-league club.

Duran started in left field and went 0-for-2 in Monday's 4-2 win over Oakland.

Duran made his first outfield start of 2024, coming against lefty Alex Wood. He was eventually pinch hit for by Evan Carter when a right-handed reliever entered the game. Duran, who started 32 games in the outfield last season, will be part of the crew that replaces the injured Wyatt Langford (hamstring), who is expected to miss 3-to-4 weeks. Duran is the lone righty-hitting outfielder in that replacement mix, joining lefties Carter and Travis Jankowski. Of the trio, Carter is expected to get the bulk of the starts. Duran wielded a capable backup bat in 2023, posting 14 home runs and a .767 OPS, but he's off to less enticing start this year (.226/.293/.264).

The Guardians selected Manzardo's contract from Triple-A Columbus on Monday. He'll serve as the Guardians' designated hitter and hit seventh in Monday's series opener versus the Tigers.

With Steven Kwan (hamstring) landing on the 10-day injured list in a corresponding move, Manzardo should get the chance to play on an everyday basis in his first taste of the big leagues. If he performs well enough, Manzardo should have a strong case for sticking around with Cleveland even after Kwan returns, as the 23-year-old is viewed as one of the organization's top hitting prospects and isn't in need of further development time in the minors. In his first full season with the Cleveland organization after coming over from Tampa Bay at the trade deadline last July, Manzardo slashed .303/.375/.642 with nine home runs, 20 RBI and 25 runs across 128 plate appearances for Columbus. Though he'll be deployed at DH on Monday, Manzardo picked up 24 starts at first base with Columbus and could be an option at the position when Josh Naylor needs a day off.

Singleton went 2-for-4 with a two-run home run Sunday against the Mariners.

Singleton has started six straight games since Jose Abreu was optioned to the minors and has tallied all three of his home runs for the season in that span. He's gone 6-for-20 overall across those six contests while striking out at just an 8.7 percent clip. With Abreu out of the picture and Joey Loperfido getting his playing time in the outfield, Singleton appears to have the first base job to himself for the foreseeable future.

Diaz went 2-for-4 with a double, a walk and two RBI on Sunday against the Mets.

Diaz is hitting just .235 across his 150 plate appearances of the season, though his results have begun to turn around of late. Sunday marked his third straight start with two hits, and he also has a double, four RBI and a run scored in that span. Diaz has only two barrels in 114 batted ball events to begin the season, though he should continue to see hits fall in at an increased clip as he's maintained a 15.3 percent strikeout rate -- in line with his career norm.

Guerrero went 2-for-4 with a walk and a grand slam during Sunday's 11-8 loss to the Nationals.

Guerrero's grand slam in the second inning off MacKenzie Gore was his fourth of the season and first in 22 games. It was also the first time he homered this season with men on base as he had collected just 11 RBI and hit just .231 coming into the contest. Despite the power outage, Guerrero is currently in the midst of an eight-game hitting streak, batting 11-for-32 (.344) with three doubles, a homer, five RBI and three runs scored during that stretch.

Naylor went 2-for-4 with a two-run home run during Sunday's 4-1 win over the Angels.

Naylor entered Sunday's game 2-for-19 in his past five games but broke out of the cold spell with a 410-foot homer in the eighth inning off Matt Moore. With eight home runs through 32 games, Naylor is well on his way to a career high in the category -- his current top mark is 20 home runs over 122 games in 2022. He boasts a monstrous .263 ISO this season.