Santana is out of the lineup for Wednesday's game against the Cubs.

With the Pirates wrapping up their series with the Cubs with a day game, manager Derek Shelton likely viewed it as an ideal time to give Santana a breather. The 37-year-old had started in each of Pittsburgh's last 12 games, producing a .680 OPS during that stretch. Connor Joe will fill in for Santana at first base and serve as Pittsburgh's cleanup hitter.

Wade was scratched from Tuesday's lineup against the Padres due to right side tightness, Maria I. Guardado of MLB.com reports.

Wade is slashing a very impressive .308/.431/.519 during the month of June, but side problems will cause him to miss Tuesday's game. The Giants will take a closer look at Wade to determine the severity of his injury, but he should be considered day-to-day for now.

Wade was scratched from the Giants' lineup ahead of Tuesday's game versus San Diego, Alex Pavlovic of NBC Sports Bay Area reports.

It's unclear at the moment why Wade was taken out of Tuesday's lineup, but the Giants will likely offer an explanation relatively soon. In the meantime, David Villar will enter to play first base in Wade's place.

Votto (shoulder/biceps) went 2-for-3 with a home run, three RBI and a walk in Monday's 5-4 win over the Rockies.

Votto made his season debut Monday after multiple surgeries and wasted no time making an impact, drilling a solo shot in the fifth inning and later adding a two-run single. He struggled with a .173/.340/.333 slash line in 22 rehab games with Triple-A Louisville prior to his MLB return. Between that, his .689 OPS in 2022 and the Reds suddenly looking like a playoff contender, it's unclear what Votto's role will be in the immediate future.

Votto (shoulder/biceps) was activated from the 60-day injured list Monday and will start at first base and bat sixth in the Reds' series opener versus the Rockies, Charlie Goldsmith of the Cincinnati Enquirer reports.

Votto had some starts and stops as he worked his way back from left shoulder and biceps surgery, but he said Monday that he feels "much more like myself." The 39-year-old slashed .162/.385/.351 with two home runs and an 11:13 K:BB over 12 games during his most recent rehab assignment with Triple-A Louisville. Since he's returning from a long-term absence, Votto will likely receive plenty of days off in the early going as the Reds ease him back into the mix while also juggle a batting order which is suddenly teeming with appealing options. Fantasy managers in shallower leagues should take a wait-and-see approach before adding Votto off the waiver wire.

Hall (thumb) was reinstated from the 60-day injured list and optioned to Triple-A Lehigh Valley on Monday.

Hall will return to the 40-man roster for the first time since he suffered a torn ligament in his right thumb in early April. The 27-year-old went 13-for-51 with six extra-base hits, including two homers, and 10 RBI over 13 games with Triple-A Lehigh Valley during his rehab assignment and he'll look to remain hot moving forward. Over 42 games with the Phillies in 2022, Hall produced a .250 average with nine homers, 16 RBI and 19 runs scored. With Bryce Harper holding down the designated hitter role in 2023, if Hall were to get called up, he'd likely operate in a platoon with Kody Clemens at first base. In a corresponding move, Dalton Guthrie was designated for assignment Monday.

Gurriel went 2-for-5 with his fourth stolen base of the season in Sunday's win over the Nationals.

The 39-year-old has alternated starts at first base with Garrett Cooper over the last week, although the latter also rotates in at DH when he isn't playing defense. Gurriel isn't exactly earning the extra opportunities, however, slashing just .222/.239/.333 through 12 games in June with zero homers and only two RBI. His value to the Marlins primarily comes from helping to keep Cooper rested and healthy, but that doesn't translate into fantasy utility.

Alonso went 0-for-4 with three strikeouts in Sunday's loss to the Cardinals.

Making an early return from a bone bruise in his wrist he'd suffered July 7 after getting hit by a pitch, Alonso was back at first base and hitting cleanup but didn't appear to be quite 100 percent, as he also committed a fielding error in the seventh inning. Per Tim Britton of The Athletic, Alonso's early return -- the original timeline called for him to miss 3-4 weeks -- was mainly due to his ability to tolerate the pain, and the 28-year-old did claim he'd been able to swing a bat without discomfort for a couple days prior to his activation. Given his massive upside, most fantasy GMs won't have the luxury of keeping Alonso on their bench until he proves he's fully recovered, but he may need a little time to regain his power stroke.

Walker went 2-for-3 with a home run, a double and three RBI in Sunday's 12-3 loss to the Guardians.

Walker got Arizona on the board with a solo shot in the second inning and added a two-run double in the fifth, but the deficit was far too much to come back from at that point. This was his third straight multi-hit effort and his second game in a row with a homer. The first baseman is up to 15 long balls, 48 RBI, 40 runs scored, 19 doubles and a stolen base while slashing a steady .270/.334/.520 through 68 games.

Clemens is out of the lineup for Sunday's game against the A's.

Clemens has a .533 OPS through 13 games in June and will head to the bench Sunday with lefty Hogan Harris on the mound for Oakland. Alec Bohm will man first base while Edmundo Sosa starts at the hot corner.