Lopez is not in the starting lineup for Saturday's game against the Red Sox.

Despite Boston sending right-hander Brayan Bello to the mound Saturday, the lefty-hitting Lopez will begin the game in the dugout while Danny Mendick starts at second base. Lopez started in the first two games of the series, going 1-for-8 with two strikeouts.

Polanco (hamstring) has been ramping up baseball activities but will require a minor-league rehab assignment before activation, MLB.com reports.

The veteran infielder took full infield practice during the Mariners' three-game road trip in Oakland earlier in the week, and there were no reported setbacks. However, manager Scott Servais confirmed before Friday's series opener against the Royals that Polanco will require at least a brief rehab assignment, which could commence at Triple-A Tacoma in the coming days.

The Blue Jays designated Biggio for assignment Friday, Mike Wilner of the Toronto Star reports.

In order to make room on the active roster for Spencer Horwitz, who was recalled from Triple-A Buffalo on Friday, the Blue Jays will push Biggio off their 40-man. The 29-year-old utility man began the year as an everyday starter, but he began losing work after slashing .200/.323/.291 with nine RBI through 130 plate appearances. Although his .614 OPS on the year represents the lowest mark of his six-year MLB career, his defensive versatility could still make him an attractive option for other organizations.

Mateo (concussion) took grounders Friday and could participate in batting practice, Jake Rill of MLB.com reports.

Mateo was able to play catch Thursday and took another step forward in his rehab from the concussion he sustained June 2. The infielder appears to be on track to return next week.

Valdez is out of the lineup for Friday's game against the White Sox, Chris Cotillo of MassLive.com reports.

Valdez will dodge a matchup with southpaw Garrett Crochet, giving way to Jamie Westbrook at second base Friday. Since Vaughn Grissom (hamstring) got hurt June 1, Valdez is 7-for-20 with three homers, eight RBI and one strikeout.

Loftin is out of the lineup for Friday's game against the Mariners.

Loftin will be out of the starting lineup for a second straight day, giving way to Adam Frazier at second base. Loftin had started six of the Royals' previous seven games, but they'll opt for the lefty-hitting Frazier on Friday.

Lowe isn't part of the starting nine for Friday's game against Baltimore, Marc Topkin of the Tampa Bay Times reports.

Lowe has generated a hit in four straight games but will take a seat with lefty Cole Irvin on the mound for the Orioles. Jose Caballero will play second base and Taylor Walls will play shortstop.

The Tigers outrighted Kennedy to Triple-A Toledo on Thursday after he cleared waivers.

Kennedy could elect free agency if he wants, but it's not clear at this point whether he will do so. If he doesn't, he'll join Toledo, where he will represent infield depth for the Tigers.

Valdez went 1-for-6 with a three-run home run and a walk in Thursday's 14-2 win over the White Sox.

Valdez turned the game into a romp with his fourth-inning blast. He's hit safely in his last five contests, going 7-for-20 (.350) with three homers and eight RBI in that span. The 25-year-old is slashing just .189/.218/.378 through 120 plate appearances, but he's added five homers, 19 RBI and 13 runs scored across 35 contests. Valdez remains in a starting role at second base while Vaughn Grissom (hamstring) is on the injured list.

Remillard cleared waivers Thursday and was sent outright to Triple-A Charlotte, Daryl Van Schouwen of the Chicago Sun-Times reports.

Remillard has been DFA'd three times since the beginning of the calendar year, and he has passed through waivers unclaimed all three times. The 30-year-old infielder has slashed .242/.342/.333 through 15 games with the White Sox but has not had the same success in Triple-A, logging a .349 OPS in 79 plate appearances.