Lopez is out of the lineup for Wednesday's game against the Angels.

The left-handed-hitting Lopez will bow out of the starting nine while the Angels send southpaw Jose Suarez to the bump. Jacob Amaya will spell Lopez at shortstop and bat ninth.

Drury is out of the lineup for Wednesday's game against the White Sox, Jeff Fletcher of The Orange County Register reports.

Drury finds himself on the bench for the fourth time in five games, with all four absences coming against right-handed starting pitchers. Jack Lopez has seemingly supplanted Drury as the Halos' top option at second base.

Horwitz is out of the lineup for Wednesday's game against the Red Sox.

Horwitz's streak of 11 consecutive starts will come to an end while he heads to the bench for the first time since Sept. 11. He'll cede his spot in the lineup to Tyler Heineman, who will handle catching duties while top backstop Alejandro Kirk gets a day off behind the plate but sticks in the starting nine as the Blue Jays' designated hitter.

Grissom is out of the lineup for Wednesday's game against the Blue Jays.

Grissom had started each of the last three games at second base, going 4-for-11 with a walk, a double, two stolen bases, two RBI and one run. The Red Sox could rotate a number of players at second base down the stretch, including Ceddanne Rafaela. Though Rafaela made each of his last five starts in center field, he may end up seeing more time at the keystone at Grissom's expense now that Tyler O'Neill has been cleared to play the outfield Wednesday after recently being held out of the lineup or limited to designated-hitter duties due to a back issue. Rafaela will join Grissom on the bench Wednesday, however, as Enmanuel Valdez gets the nod at second base.

Frazier is out of the lineup for Wednesday's game against the Nationals.

The lefty-hitting Frazier will take a seat for the third game in a row while the Royals face a third consecutive left-handed starting pitcher (DJ Herz). Frazier still looks to have a hold on a strong-side platoon role in right field, but Tommy Pham will occupy the position Wednesday.

Yorke will start in right field and bat eighth in Wednesday's game against the Brewers.

After making each of his last three starts at second base, Yorke will shift to the outfield Wednesday while normal right fielder Bryan De La Cruz gets a day off. Yorke has now picked up eight starts in the Pirates' last nine games and has produced a .280/.296/.400 slash line with one home run and two steals since being called up from Triple-A Indianapolis on Sept. 16. He should be in store for near-everyday playing time in the final week of the season.

Gonzalez is absent from the lineup for Wednesday's contest in Toronto, Alex Speier of The Boston Globe reports.

Gonzalez had started three of the previous four tilts but will begin the series finale in Toronto on the bench. Nick Sogard will handle third base for the Red Sox on Wednesday.

India (head) is out of the lineup for Wednesday's game against the Guardians.

India was lifted from Tuesday's 6-1 loss after being hit in the helmet by a pitch a couple innings after his final plate appearance of the night and is being evaluated under the concussion protocol. The Reds haven't confirmed that India has been diagnosed with a concussion, so while he'll step out of the lineup Wednesday, he can be considered day-to-day heading into the club's season-ending series with the Cubs this weekend. Santiago Espinal will check in for India at second base in the series finale in Cleveland.

Gelof went 1-for-3 with an RBI sacrifice fly, a stolen base and a run in a win over the Rangers on Tuesday.

Gelof snapped a 3-3 tie in the sixth inning with his sacrifice fly, which plated Shea Langeliers. He eventually scored the game-winning run on Jacob Wilson's walk-off single in the penultimate night game for the Athletics at Oakland Coliseum. The eventful night was an extension of a productive all-around month for Gelof despite some persistent contact issues, as he's generated a .278 average, .715 OPS, eight extra-base hits, seven RBI, five steals and nine runs across 84 September plate appearances.

Altuve is not in the lineup for Wednesday's game versus the Mariners, Chandler Rome of The Athletic reports.

Altuve will get a breather one day after the Astros wrapped up another division title. Shay Whitcomb will handle second base and bat seventh Wednesday.