Rengifo is out of the lineup for Wednesday's game against the Orioles.

Brandon Drury will step in at second base Wednesday, after Rengifo had occupied the position in each of the previous three games while going 1-for-11 with a run scored. Despite taking a seat Wednesday, Rengifo should have a path to steady playing time in the infield until the Angels return one of Jared Walsh (migraines) or Anthony Rendon (groin) from the 10-day injured list.

Altuve (thumb) will appear in a rehab game Wednesday for Double-A Christi before potentially being reinstated from the 10-day injured list prior to Houston's game Friday versus Oakland, Brian McTaggart of MLB.com reports.

Altuve has struggled thus far in his rehab stint with a .056 average over 18 at-bats, but the reps are far more important than the results at this stage. Even if the 33-year-old needs an extra couple of days, he looks like he's on pace to rejoin the Houston lineup for his season debut at some point over the weekend. Mauricio Dubon has been serving as the primary replacement at second base for Altuve this season and would presumably move into a utility role once Altuve is activated.

Espinal is will start at second base and bat ninth Wednesday against the Yankees.

With Whit Merrifield covering left field Wednesday while Kevin Kiermaier (illness) gets the night off, the keystone is opened up for Espinal. The 28-year-old infielder has put up a woeful .477 OPS across 71 plate appearances this season.

Dubon is out of the lineup Wednesday against the Cubs.

Dubon has been hot with the bat as of late, but he'll put his eight-game hitting streak on hold while he rests in the series finale with the Cubs. David Hensley will step in for Dubon as the Astros' starting second baseman.

The Nationals will call up Alu from Triple-A Rochester prior to Wednesday's game against the Marlins, Bobby Blanco of MASNSports.com reports.

Alu was optioned back to Triple-A on Monday following Corey Dickerson's return from the injured list, but he'll rejoin the Nationals just two days later with first baseman/designated hitter Joey Meneses going on the paternity list. According to Blanco, Alu may not arrive in Miami prior to Wednesday's 6:40 p.m. ET opening pitch, so he might not be ready to play until Thursday's series finale.

McNeil is out of the lineup for Wednesday's game against the Rays.

The Mets don't have a single left-handed hitter (not including switch hitters) in Wednesday's lineup against southpaw Josh Fleming. Eduardo Escobar is playing second base and batting second while McNeil sits.

Valdez is out of the starting lineup for Wednesday's tilt against the Mariners, Gabrielle Starr of the Boston Herald reports.

Valdez will grab a seat on the bench to open the finale against Seattle with left-hander Marco Gonzales on the mound. Pablo Reyes will handle duties at second base and hit seventh in Valdez's absence.

Hernandez (hamstring) is hitting sixth and playing shortstop against the Mariners on Wednesday, Gabrielle Starr of the Boston Herald reports.

Hernandez returns after missing three games with a strained left hamstring. The veteran infielder will handle shortstop duties with Pablo Reyes moving to second base and Enmanuel Valdez beginning Wednesday's contest on the bench.

Wisely is out of the lineup for Wednesday's game against the Phillies, Alex Pavlovic of NBC Sports Bay Area reports.

Wisely has been handling a near-everyday role for most of May while bouncing between second base and center field, but his time as a regular in the San Francisco lineup looks to be over now that the Giants have recently welcomed Brandon Crawford and Mike Yastrzemski back from the injured list. The rookie will be on the bench for the third game in a row Wednesday.

The Mets optioned Guillorme to Triple-A Syracuse on Wednesday.

He'll head down to the minors to clear room on the 26-man active roster for corner infielder Mark Vientos, who was called up from Triple-A. Guillorme is the Mets' best and most versatile defensive infielder, but his bat has been even weaker than usual this season and the floundering New York offense could benefit from the higher offensive upside that Vientos offers.