Editor's Note: In Week 6, we've got four teams on bye, but that doesn't matter too much for quarterback, where there are typically more Fantasy viable players than spots to fill. However, the struggles of some of our projected stars could leave you in a pinch — it's fair to wonder if you can just Aaron Rodgers in your lineup these days, let alone the likes of Jared Goff or Baker Mayfield. Whether you're just playing the matchups or find yourself in need of a surprise replacement, Jamey Eisenberg's Start 'Em & Sit 'Em column is the place to find the answer at quarterback. Jamey Eisenberg has his start and sit calls for QB ready to go for Week 6, so dig in to see what to expect for this week.

START 'EM & SIT 'EM
Quarterbacks
Start 'Em
Projections powered by Sportsline
IND Indianapolis • #2
Age: 39 • Experience: 16 yrs.
Weekly Breakdown
MATCHUP
@ ARI ATL -2.5 O/U 51.5
OPP VS QB
31st
PROJ PTS
23.6
QB RNK
6th
YTD Stats
PAYDS
1655
RUYDS
55
TD
12
INT
7
FPTS/G
25
Ryan is quietly having another outstanding Fantasy season, and he comes into Week 6 having scored at least 20 Fantasy points in 16 of his past 21 games going back to last year. He's passed for at least 300 yards in every game this season, and he has at least three touchdowns in three of his past four games. The Cardinals have allowed four of five quarterbacks to score at least 22 Fantasy points this season, and Ryan and Murray should put on a show in Arizona on Sunday.
DAL Dallas • #4
Age: 31 • Experience: 9 yrs.
Weekly Breakdown
MATCHUP
@ NYJ DAL -7 O/U 43
OPP VS QB
7th
PROJ PTS
22
QB RNK
8th
YTD Stats
PAYDS
1606
RUYDS
122
TD
12
INT
6
FPTS/G
26
Sometimes bad performances can lead to good Fantasy production, which happened with Prescott in Week 5 against Green Bay. He struggled with three interceptions in a 34-24 loss, but Prescott still had 463 passing yards, two touchdowns and 27 rushing yards, which was 26 Fantasy points. He's now scored at least 25 Fantasy points in four of five games, and I like him to keep rolling this week at the Jets. Only Tom Brady in Week 3 has more than 17 Fantasy points against the Jets this season, but I expect Prescott will do well in this matchup. Keep him active in all leagues.
CLE Cleveland • #5
Age: 30 • Experience: 10 yrs.
Weekly Breakdown
MATCHUP
vs CAR CAR -2 O/U 47.5
OPP VS QB
10th
PROJ PTS
20
QB RNK
13th
YTD Stats
PAYDS
1371
RUYDS
37
TD
11
INT
5
FPTS/G
22.2
Winston will look to extend his streak of games with at least 20 Fantasy points to four, which is something he's only done once in his career. In 2016, Winston once had a four-game streak with at least 20 Fantasy points, and I expect him to match that this week against the Panthers. Carolina has allowed a quarterback to score at least 20 Fantasy points in two of the past three games, including Gardner Minshew in Week 5. And Winston has improved since he scored just 14 Fantasy points against the Panthers in Week 2, with Carolina's defense banged up since then as well.
LV Las Vegas • #15
Age: 28 • Experience: 6 yrs.
Weekly Breakdown
MATCHUP
vs NO JAC -1 O/U 44.5
OPP VS QB
28th
PROJ PTS
16.2
QB RNK
11th
YTD Stats
PAYDS
1279
RUYDS
124
TD
9
INT
1
FPTS/G
20.6
Minshew continues to impress in Fantasy and reality, and he's scored at least 20 Fantasy points in four of the five games that he's played. He just had his best outing in arguably his toughest matchup at Carolina in Week 5, and he scored 24 Fantasy points. He has another tough test in Week 6 against the Saints, although New Orleans has allowed four of five quarterbacks to score at least 21 Fantasy points this year. I like Minshew as a low-end No. 1 quarterback in Week 6, and hopefully Minshew Mania keeps going for at least one more week.
DET Detroit • #16
Age: 30 • Experience: 9 yrs.
Weekly Breakdown
MATCHUP
vs SF LAR -3 O/U 50.5
OPP VS QB
2nd
PROJ PTS
20.8
QB RNK
9th
YTD Stats
PAYDS
1649
RUYDS
13
TD
7
INT
7
FPTS/G
18.4
Goff has obviously struggled this season, and he has a tough matchup this week against the 49ers. San Francisco has allowed one quarterback to score more than 17 Fantasy points, which was Andy Dalton in Week 2 when he scored 22. But Goff's track record against the 49ers is impressive since he's averaging 26.7 Fantasy points per game in his past three meetings with San Francisco. And he's averaging 22.5 Fantasy points in two home games this year. He also has the chance to fall into quality production based on volume since he's attempted 117 pass attempts over the past two weeks. With Todd Gurley (quad) hurt, Goff could have to carry the offense once again, which makes him a low-end starter in Week 6.
Sleepers
Projections powered by Sportsline
CAR Carolina • #14
Age: 37 • Experience: 14 yrs.
Weekly Breakdown
MATCHUP
@ BAL BAL -11.5 O/U 48
OPP VS QB
15th
PROJ PTS
18.2
QB RNK
17th
YTD Stats
PAYDS
1412
RUYDS
16
TD
8
INT
4
FPTS/G
17.6
Dalton's Fantasy production in Week 5 against Arizona was about what I expected. I thought he would do well with a limited ceiling, and he scored 22 Fantasy points. That's now three games with at least 22 Fantasy points in five outings, and he has just one game with fewer than 18 points on the season. I can see him in that range again in Week 6 at Baltimore. In his past three games against the Ravens, Dalton has 698 passing yards, nine touchdowns and no interceptions, and he's scored at least 22 Fantasy points in each outing.
PIT Pittsburgh • #4
Age: 28 • Experience: 6 yrs.
Weekly Breakdown
MATCHUP
@ TB CAR -2 O/U 47.5
OPP VS QB
27th
PROJ PTS
19.4
QB RNK
18th
YTD Stats
PAYDS
674
RUYDS
3
TD
5
INT
0
FPTS/G
16
The hope for Allen this week against Tampa Bay in London would be that he does what each of the past three quarterbacks did against the Buccaneers. Daniel Jones, Jared Goff and Teddy Bridgewater each scored at least 24 Fantasy points against Tampa Bay, and hopefully Allen gets in that range. We have only seen Allen have one game over 13 Fantasy points, which was Week 3 in his first start at Arizona. Since then, he's combined for 16 Fantasy points against Houston and Jacksonville. But this matchup is easier given what the Buccaneers defense has looked like the past three games, so hopefully Allen takes advantage of this matchup.
LAR L.A. Rams • #9
Age: 36 • Experience: 16 yrs.
Weekly Breakdown
MATCHUP
@ GB GB -4 O/U 47
OPP VS QB
7th
PROJ PTS
17.2
QB RNK
13th
YTD Stats
PAYDS
1,122
RUYDS
54
TD
9
INT
2
FPTS/G
23.2
The Packers started off the season dominating opposing quarterbacks, holding Mitchell Trubisky, Kirk Cousins and Joe Flacco to a combined 22 Fantasy points. But that wasn't exactly the best competition. In the past two games against Carson Wentz and Dak Prescott, those quarterbacks each scored at least 25 Fantasy points, and Stafford could be in that range. He's already scored at least 28 Fantasy points in two of four starts this year, and he has 1,480 passing yards, 11 touchdowns and one interception in his past five games against Green Bay, with multiple touchdowns in each game over that span. And in his past seven games coming off a bye, Stafford is averaging 19.1 Fantasy points per game, with four games of at least 20 Fantasy points in those outings.
Sit 'Em
Projections powered by Sportsline
KC Kansas City • #11
Age: 31 • Experience: 9 yrs.
Weekly Breakdown
MATCHUP
@ MIN MIN -3 O/U 44
OPP VS QB
11th
PROJ PTS
16.2
QB RNK
16th
YTD Stats
PAYDS
1152
RUYDS
59
TD
11
INT
2
FPTS/G
22.4
Wentz didn't have to do much last week against the Jets, and he scored just 13 Fantasy points in a 31-6 victory. He might have similar production this week, although it will be a much tougher opponent on the road. The Vikings allow an average of just 16.6 Fantasy points per game to opposing quarterbacks, and only Matt Ryan in Week 1 scored more than 20 Fantasy points against this defense. Wentz is averaging 22.0 Fantasy points per game in two road outings this season, but I expect this to be a tough test. I would only start Wentz in two-quarterback and Superflex leagues.
TB Tampa Bay • #6
Age: 29 • Experience: 7 yrs.
Weekly Breakdown
MATCHUP
vs SEA SEA -1.5 O/U 47.5
OPP VS QB
16th
PROJ PTS
16.2
QB RNK
20th
YTD Stats
PAYDS
1247
RUYDS
0
TD
4
INT
8
FPTS/G
10.8
Mayfield has been a disaster so far this season, and he just had his worst game of the year in Week 5 at San Francisco. He scored minus-2 Fantasy points with 100 passing yards, no touchdowns and two interceptions. He has yet to throw multiple touchdowns in any game this year, and his right shoulder is a little banged up after Monday's loss to the 49ers. We hope he can shake it off this week against the Seahawks, but Seattle has limited Kyler Murray and Jared Goff to just 34 Fantasy points combined in the past two games.
ATL Atlanta • #18
Age: 36 • Experience: 13 yrs.
Weekly Breakdown
MATCHUP
vs PHI MIN -3 O/U 44
OPP VS QB
17th
PROJ PTS
15.6
QB RNK
19th
YTD Stats
PAYDS
1041
RUYDS
40
TD
6
INT
2
FPTS/G
13.8
Cousins quieted some doubters with his performance last week against the Giants, but we expected him to play well in that matchup. It was against an inferior opponent, and he scored a season-high 24 Fantasy points. While the Eagles defense has been favorable to opposing quarterbacks – Case Keenum, Ryan and Rodgers scored at least 24 Fantasy points – I don't trust Cousins when he's playing a good team, even at home. He's someone to avoid in most formats this week.
DET Detroit • #10
Age: 32 • Experience: 10 yrs.
Weekly Breakdown
MATCHUP
@ JAC JAC -1 O/U 44.5
OPP VS QB
20th
PROJ PTS
14
QB RNK
21st
YTD Stats
PAYDS
849
RUYDS
32
TD
6
INT
2
FPTS/G
16.3
Bridgewater was fantastic in Week 5 against Tampa Bay. He completed 26 of 34 passes for 314 yards, four touchdowns and one interception, and he scored a season-high 34 Fantasy points. He now has at least 20 Fantasy points in two of three starts for the injured Drew Brees (thumb), but this could be a tough matchup for him on the road, especially if Jalen Ramsey (back) returns to the Jaguars' secondary. Jacksonville has allowed one quarterback to score more than 15 Fantasy points in the past four games, which was Joe Flacco in Week 4 with 28 points in the first game Ramsey was out. I don't see Bridgewater following suit in this matchup on the road.
Bust Alert
Projections powered by Sportsline
IND Indianapolis • #17
Age: 42 • Experience: 17 yrs.
Weekly Breakdown
MATCHUP
vs PIT LAC -6.5 O/U 41.5
OPP VS QB
12th
PROJ PTS
18.4
QB RNK
14th
YTD Stats
PAYDS
1465
RUYDS
24
TD
7
INT
4
FPTS/G
17.8
I'm a believer in this Steelers defense, and it has been tough against opposing quarterbacks of late. After giving up back-to-back games with at least 30 Fantasy points in the first two weeks of the season against Tom Brady and Russell Wilson, Pittsburgh has limited Garoppolo, Dalton and Lamar Jackson to a combined 26 Fantasy points over the past three games. Rivers just lost another offensive lineman in center Mike Pouncey (neck), who was placed on injured reserve, and Rivers scored just four Fantasy points in Week 5 against Denver. I can see another week of limited production, and Rivers is a low-end starter at best in most formats.