Brissett completed 47 of 57 passes for 452 yards, two touchdowns and two interceptions and rushed twice for minus-2 yards during Sunday's 41-22 loss to the 49ers.

Working without No. 1 WR Marvin Harrison (concussion) on Sunday, Brissett set an NFL regular-season record for a single game with his 47 completions, helping fuel a pair of 100-yard receiving efforts from WR Michael Wilson (15-185-0 on 18 targets) and TE Trey McBride (10-115-1 on 11 targets). The pass-heavy approach from the Cardinals likely was spurred by being down double-digit points as soon as the 13:39 mark of the second quarter, and the closest margin after that point was nine points before the 49ers tacked on a pair of field goals in the last 1:01 of the first half. In five starts in place of Kyler Murray (foot, IR), Brissett has averaged 314 yards per game to go with a 10:3 TD:INT on 67 percent passing. Brissett's next chance to continue leading Arizona's offense is next Sunday versus the Jaguars.

Purdy (toe) completed 19 of 26 pass attempts for 200 yards and three touchdowns while losing seven yards on his only carry in Sunday's 41-22 win over the Cardinals.

Purdy made a triumphant return from a turf toe injury that cost the signal-caller six weeks of action, tossing a trio of touchdowns with no turnovers in a decisive victory over a division opponent. The 25-year-old connected in the end zone with top weapons Christian McCaffrey and George Kittle (twice) as San Francisco's offense looked as healthy as it has since Week 1. Purdy had thrown as many touchdowns (four) as interceptions over his previous two starts this season, neither of which he exited at full strength. Assuming that he escaped Sunday's win with a clean bill of health, fantasy managers can feel comfortable again starting Purdy against the Panthers on Monday Night Football in Week 12.

Herbert completed 10 of 18 passes for 81 yards with no touchdowns and one interception while adding three rushes for 21 yards in the Chargers' 35-6 loss to the Jaguars on Sunday.

The sixth-year pro put together a performance that was about as poor as his numbers indicated, with Herbert finishing with a career-low yardage total. Herbert was sacked just twice but appeared to be under constant duress, and he failed to throw a touchdown pass for the first time all season before being pulled for Trey Lance in the fourth quarter. The Chargers will now have a Week 12 bye to regroup before returning to action in a Week 13 home matchup against the Raiders on Sunday, Nov. 30.

Stafford completed 15 of 28 passes for 130 yards and two touchdowns in Sunday's 21-19 win over the Seahawks.

Stafford's yardage total dipped as both pass defenses stepped up in the battle for first place in the NFC West, but he avoided mistakes and improved his TD:INT to 22:0 over the past seven starts, while the Rams picked off Sam Darnold four times. Stafford threw a one-yard touchdown pass to Davante Adams in the first quarter and a six-yard touchdown pass to Colby Parkinson in the fourth quarter. The Rams will likely lean more on Stafford's arm in Week 12 against a beatable Buccaneers secondary that just allowed six total touchdowns to fellow potential MVP candidate Josh Allen.

Howell (coach's decision) is inactive but operating as the Eagles' emergency third quarterback versus the Lions on Sunday Night Football.

Howell will once again operate as the No. 3 QB in Week 11, and he'd only enter the game if Jalen Hurts and Tanner McKee are forced out. The 25-year-old has yet to appear in a regular-season contest this year.

Mayfield completed 16 of 28 passes for 173 yards with one touchdown and one interception while adding five carries for 39 yards and another score in the Buccaneers' 44-32 loss to the Bills on Sunday. He also lost a fumble.

Mayfield fought hard in trademark fashion all afternoon, often taking matters into his own hands when an aggressive Bills defense applied pressure. Buffalo's talented secondary did limit Mayfield to his third lowest passing yardage tally of the campaign. Mayfield connected with Sean Tucker for his one touchdown pass from 28 yards out, a play he preceded with a four-yard scoring run early in the second quarter. Mayfield and the Bucs next set their sights on a Week 12 road showdown against the Rams next Sunday night.

Gabriel (concussion) won't return to Sunday's game against the Ravens.

With Gabriel out for the remainder of Sunday's contest, Shedeur Sanders will handle the Browns' QB duties versus the Ravens. Gabriel will thus look to gain medical clearance ahead of next weekend's contest against the Raiders.

Gabriel is being evaluated for a possible concussion during Sunday's game against the Ravens.

With Gabriel out of the contest, Shedeur Sanders is in at QB for the Browns. Prior to his exit, Gabriel completed seven of his 10 pass attempts for 68 yards and carried twice for two yards.

McCarthy completed 16 of 32 passes for 150 yards, one touchdown and two interceptions in Sunday's 19-17 loss to the Bears.

McCarthy turned 19 first-half pass attempts into just 74 yards and threw two interceptions as the Vikings took a 10-3 deficit into the locker room. He didn't complete another pass until less than three minutes remained in the fourth quarter, but McCarthy then proceeded to engineer a go-ahead drive capped by a 15-yard touchdown pass to Jordan Addison, which gave the Vikings a 17-16 lead. Chicago answered with a game-winning field goal on the game's final play, overshadowing McCarthy's late-game heroics. The struggling McCarthy has thrown for 158 yards or fewer in four of five starts heading into a Week 12 trip to Green Bay.

Cousins completed six of 14 passes for 48 yards with no touchdowns or interceptions and added one rush for two yards in the Falcons' 30-27 overtime loss to the Panthers on Sunday.

Marc Raimondi of ESPN.com reports Michael Penix suffered a knee injury in the third quarter on a hit he took on an incomplete pass. That led to Cousins seeing his second dose of extended action this season, and although his final line underscores the fact he was relatively ineffective, he did manage to lead Atlanta to two field goals, including the game-tying kick with 16 seconds remaining in regulation. If Penix ultimately is unable to suit up for next Sunday's road divisional clash against the Saints, Cousins would be in line to draw his second start of the season.