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Tanner McKee QB | PHI
Eagles' Tanner McKee: Replacing Dalton as No. 2 quarterback
McKee is expected to be active for Sunday's game against the Rams as the top backup to starter Jalen Hurts, while Andy Dalton serves as the Eagles' No. 3 quarterback, Mike Garafolo of NFL Network reports.
Despite operating as Hurts' primary backup in 2025, McKee slid to third on the depth chart entering the 2026 season after the Eagles acquired Dalton in a trade with the Panthers back in March. Dalton didn't see any snaps on the season until midway through the second quarter of Monday's 27-7 loss to the Bears, when Hurts made a brief exit from the contest to get checked for a concussion. After three consecutive Saquon Barkley carries got the Eagles near the goal line, Dalton proceeded to throw a costly interception in the end zone on his lone pass attempt before Hurts returned for the next possession. The gaffe appears to have resulted in Dalton turning the backup gig over to McKee, at least for one week.
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Baker Mayfield QB | TB
Buccaneers' Baker Mayfield: Could miss up to six weeks
Mayfield's dislocated right thumb could keep him out anywhere from 3-to-6 weeks, depending on how quickly he's able to resume gripping the football without issue, Adam Schefter of ESPN reports.
Head coach Todd Bowles previously acknowledged that Mayfield would miss at least three weeks due to the injury, which he sustained in last Sunday's loss to the Vikings. Though Mayfield was cleared of any tendon or ligament damage and won't need surgery on the thumb on his throwing hand, the two-time Pro Bowler required stitches to close a wound caused by the dislocation. Despite facing a loose recovery timeline that could keep him out for more than four games, Mayfield avoided placement on injured reserve Saturday, which signals that the Buccaneers are still holding out hope that he might be ready to go after a three-week absence. For however long Mayfield ends up being sidelined, the Buccaeneers will turn to undrafted rookie Jalon Daniels to direct the offense, beginning with Sunday's game versus Green Bay.
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Riley Leonard QB | IND
Colts' Riley Leonard: No. 3 quarterback for Week 4
Leonard is inactive for Sunday's game against the Commanders in London as the Colts' emergency No. 3 quarterback.
Leonard hasn't been active for any of the Colts' first four games after Anthony Richardson beat him out for the No. 2 job coming out of the preseason. The second-year player out of Notre Dame will only be available in the event both starter Daniel Jones and Richardson are unable to finish the game.
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Anthony Richardson QB | IND
Colts' Anthony Richardson: Remaining No. 2 quarterback
Richardson is active for Sunday's game against the Commanders in London.
Richardson has yet to take any snaps this season, but he'll suit up for a fourth straight game as Daniel Jones' backup after securing the No. 2 job coming out of the preseason. Meanwhile, second-year player Riley Leonard will be inactive as the Colts' emergency No. 3 quarterback.
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Jake Haener QB | NYG
Giants' Jake Haener: Elevated, likely to be backup QB in Week 4
The Giants elevated Haener from their practice squad Saturday, Dan Salomone of the Giants' official site reports.
Haener was active for last Sunday's win against Tennessee but didn't get into the game. He was subsequently waived Monday after New York traded for J.J. McCarthy, but Haener then rejoined New York as part of the team's practice squad Wednesday. His elevation for Week 4 likely means Haener will back up Jameis Winston for a second straight week, as Jordan Raanan of ESPN.com notes that McCarthy likely hasn't yet had enough time to familiarize himself with the Giants' playbook.
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Easton Stick QB | TB
Buccaneers' Easton Stick: Set to work as No. 2 QB in Week 4
The Buccaneers elevated Stick from their practice squad to their active roster Saturday ahead of Sunday's matchup against Green Bay, Scott Smith of the team's official site reports.
Stick signed with Tampa Bay's practice squad in early September to serve as organizational QB depth. He'll now get a chance to be active on game day due to starter Baker Mayfield being set to miss multiple weeks with a thumb injury. Undrafted rookie Jalon Daniels is slated to start behind center during Mayfield's absence, and Stick will provide a veteran option -- albeit one with only six career games of regular-season action -- should Daniels need to exit or struggle significantly.
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Aidan O'Connell QB | LV
Raiders' Aidan O'Connell: Clear for Week 4
O'Connell (personal) had his injury designation for Sunday's Week 4 matchup against Kansas City cleared on Saturday, Ryan McFadden of ESPN.com reports.
O'Connell missed each of Las Vegas' past two games while dealing with a personal matter. He's now back with the team and eligible to play Sunday, though he'll likely be a healthy scratch with Kirk Cousins and Fernando Mendoza both ahead of him on the QB depth chart.
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Case Keenum QB | CHI
Bears' Case Keenum: Expected to back up Bagent vs. NYJ
Ian Rapoport of NFL Network reports that Keenum is expected to serve as the backup quarterback to Tyson Bagent against the Jets on Sunday.
Keenum was under center for Week 3 and led the Bears to a 27-7 win over the Eagles, when he threw for 247 yards and two touchdowns while adding a rushing TD. However, Bagent has taken the majority of first-team reps during Week 4 prep, with Caleb Williams (hamstring) ruled out for a second consecutive week. Head coach Ben Johnson has yet to name a starter, but for now, it looks like Bagent will be the starter Sunday while Keenum stays ready as the QB2.
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Tyson Bagent QB | CHI
Bears' Tyson Bagent: Expected to start Sunday
Bagent is expected to start Sunday versus the Jets after getting first-team reps in practice, Ian Rapoport of NFL Network reports. However, coach Ben Johnson has not yet confirmed the plan.
Bagent was the backup to Case Keenum in Week 3 against Philadelphia with Caleb Williams (hamstring) sidelined due to a hamstring injury. That arrangement likely had something to do with Bagent coming off a concussion, which resulted in Keenum handling much of the first-team reps in practice during the week. It appeared Keenum may have seized the starting job for Week 4 (with Williams still out of action) after leading Chicago to a win against the Eagles while throwing for 247 yards and two touchdowns, but Bagent's work with the first team this week during practice suggests the script is flipping again. With that said, Johnson has refused so far to announce a Week 4 starter at QB, so it can't yet be said for certain what roles Keenum and Bagent will have this weekend.
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Trey Lance QB | LAC
Chargers' Trey Lance: Officially questionable for Week 4
Lance (groin) is listed as questionable for Sunday's game against Seattle.
Lance has been working through a groin issue as of late, though he was cleared to suit up for Week 3 against the Bills. He figures to do the same Sunday, but if Lance is not cleared to play, then DJ Uiagalelei would be in line to serve as the Chargers' backup quarterback behind Justin Herbert.