Vaki (thumb) is active for Sunday's game against the Rams.

Vaki has been dealing with a thumb issue throughout December but hasn't missed any time because of the injury. With Jahmyr Gibbs and David Montgomery both healthy, Vaki probably won't get much (if any) work on offense against Los Angeles, though he consistently has served as a core special-teamer.

Ouzts (coach's decision) is inactive for Sunday's game against the Colts.

Ouzts missed four games earlier in the season due to an ankle injury, but he will be a healthy scratch for Sunday's game. Brady Russell will be the lone fullback on the active roster for Week 15.

Strong (coach's decision) is inactive for Sunday's game against the Broncos, Mike Spofford of the Packers' official site reports.

Strong was elevated from the practice squad Saturday, but his services are not needed Sunday after Josh Jacobs (knee) and Emanuel Wilson (illness) were both cleared to play. Strong has been elevated three times this season, so he'll need to be signed to the active roster in order to play for the Packers for the rest of 2025.

Knight (ankle) has been ruled out for the remainder of Sunday's game versus the Texans.

Knight logged just one carry for minus-2 yards before exiting and being carted to he locker room in the first quarter. The 24-year-old has been serving as the Cardinals' top running back due to James Conner (foot) and Trey Benson (knee) both being out for the season. Over the last eight games prior to Week 15, Knight recorded 77 rushes for 260 yards and three touchdowns to go along with 21 catches (on 30 targets). His next opportunity to take the field will come Week 16 versus the Falcons on Sunday, Dec. 21. In Knight's absence, Emari Demercado and Michael Carter will carry the load at running back.

James (coach's decision) is inactive for Sunday's matchup against Tennessee.

James has yet to make his NFL debut and has consistently been a healthy scratch on game days. The rookie fifth-rounder is firmly behind all of Christian McCaffrey, Brian Robinson and Isaac Guerendo on the 49ers' RB depth chart.

McCaffrey (back) is active for Sunday's game against the Titans.

After an illness impacted his practice participation Wednesday and Thursday, McCaffrey worked fully Friday and initially approached Sunday's contest minus a designation. However, on Saturday the running back was added the 49ers' Week 15 injury report due to a back issue. With his availability versus Tennessee confirmed, McCaffrey is back on track to pace his team's backfield in the absence of any in-game setbacks. Next up for San Franciso's backfield touches if McCaffrey is hampered at all would be Brian Robinson and Isaac Guerendo.

Wilson (illness) is active for Sunday's contest at Denver, Mike Spofford of the Packers' official site reports.

Wilson was tacked on to the Packers' Week 15 injury report Saturday due to an illness and deemed questionable for Sunday. Adam Schefter of ESPN later reported that Wilson showed up to team facilities earlier Saturday under the weather and was sent home with medication with the aim he'd feel well enough to play this weekend. Wilson at least will be available to Green Bay's offense, but he may only be available in an emergency capacity behind Josh Jacobs (knee), while Chris Brooks also is on hand for snaps.

Jacobs (knee) is listed as active Sunday at Denver, Mike Spofford of the Packers' official site reports.

Jacobs has been tending to a knee injury since he sustained it during a Week 11 win at the Giants, sitting out Week 12 but leading the Packers backfield the last two games. He then experienced renewed stiffness and swelling in the knee in the wake of last Sunday's victory against the Bears, sitting out practice Wednesday and Thursday before logging a limited session Friday. Despite Jacobs being tagged as questionable entering the weekend, Adam Schefter of ESPN reported Saturday evening that he was expected to play Week 15, which has been confirmed. With No. 2 RB Emanuel Wilson dealing with an illness but still active Sunday, Jacobs should be Green Bay's primary option out of the backfield, while Chris Brooks also is on hand for snaps.

Marks exited Sunday's game against the Cardinals with an ankle injury and is questionable to return.

Before his departure from the contest, Marks carried the ball seven times for 30 yards and caught his only target for eight yards. He also was credited with his sixth touchdown of the season on a strange play, when a goal-line snap went through C.J. Stroud's legs straight to Marks, who took it into the end zone on what was ruled a fumble recovery rather than a carry. If the running back ends up missing the rest of the game, Dare Ogunbowale and Jawhar Jordan are likely to assume most of the touches out of the backfield.

Knight exited Sunday's game at Houston due to an ankle injury, Darren Urban of the Cardinals' official site reports.

Knight had his left ankle pinned under a Texans defender as he was tackled to the turf early in the first quarter. Per Urban, Knight was carted to the locker room and soon after was deemed questionable to return. Michael Carter and Emari Demercado are left as the likeliest candidates to carry Arizona's backfield for as long as Knight is sidelined.