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Jack Stoll TE | SF
49ers' Jack Stoll: Elevated for Week 5
The 49ers elevated Stoll from the practice squad to the active roster Saturday.
The addition of Stoll gives the 49ers extra depth at tight end behind George Kittle, Luke Farrell and Brayden Willis. Stoll appeared in 15 regular-season games for the Saints in 2025, contributing on both offense and special teams and finishing with six catches on 11 targets for 46 yards and a touchdown.
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Mykel Williams DE | SF
49ers' Mykel Williams: In line to make 2026 debut Sunday
The 49ers activated Williams (knee) from the reserve/PUP list Saturday, and he no longer carries an injury designation into Sunday's NFC West tilt against the Seahawks.
Williams is set to play in his first game since he tore his ACL in early November of 2025. It wouldn't be surprising to see the 2025 first-rounder operate under a snap count against Seattle. Nevertheless, the return of Williams is a welcome one for the 49ers, especially with Nick Bosa set to miss a third consecutive game due to a calf injury.
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Za'Darius Smith DE | ATL
Falcons' Za'Darius Smith: Won't play against Baltimore
Smith (concussion/neck) has been downgraded to out for Sunday's game against the Ravens, Tori McElhaney of the Falcons' official site reports.
Smith entered the league's concussion protocol during the Falcons' Week 4 win over the Saints on Monday. He drew the questionable tag after practicing in a limited capacity Friday, but it looks like he won't clear protocol before Sunday's game. Samson Ebukam (hamstring) is also listed as questionable, so Jared Ivey, Bralen Trice and Cameron Thomas are all in line for more defensive snaps against Baltimore. Smith's next chance to play is Week 6 against the Bears on Sunday, Oct. 18.
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Theo Wease Jr. WR | LAC
Chargers' Theo Wease: Signed to Bolts' 53-man roster
The Chargers signed Wease off the practice squad to the active roster Saturday.
The Chargers are thin at wide receiver ahead of Sunday's game against the Broncos, given that both Quentin Johnston (chest) and Brenen Thompson (quadriceps) are ruled out while Ladd McConkey (foot) is listed as questionable despite not practicing all week. If McConkey is not cleared to play, then Wease would step into the WR4 role behind Tre' Harris, Marquez Valdes-Stantling and Derius Davis. Wease joined the Chargers' practice squad in early September after failing to make the Dolphins' 53-man roster at the end of training camp in late August.
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Trey Amos CB | WAS
Commanders' Trey Amos: Downgraded to out for Week 5
Amos (ankle) has been downgraded to out for Sunday's game against the Giants.
Amos will remain on injured reserve for at least one more week after his 21-day practice window was opened earlier this week. His next chance to suit up will be next Monday night against the 49ers.
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Scott Matlock RB | LAC
Chargers' Scott Matlock: Taken off injured reserve
The Chargers activated Matlock (foot) from injured reserve Saturday, but he's still listed as questionable for Sunday's game against the Broncos.
Matlock was designated to return from injured reserve Wednesday, and he drew the questionable tag after logging a full practice Friday. The fact that he was activated from IR indicates that Matlock has a good chance of making his 2026 regular-season debut Sunday.
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Jeremy McNichols RB | WAS
Commanders' Jeremy McNichols: Ruled out for Week 5
McNichols (quadriceps) has been ruled out for Sunday's game against the Giants.
McNichols remains on injured reserve, so his next chance to suit up will be Week 6 against the 49ers on Monday night. The Commanders will continue to roll with Jacory Croskey-Merritt, Rachaad White, Austin Ekelers and special-teamer Craig Reynolds out of the backfield.
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Van Jefferson WR | WAS
Commanders' Van Jefferson: Up from practice squad
The Commanders elevated Jefferson from the practice squad ahead of Sunday's game against the Giants.
With Stefon Diggs (hamstring) and Jaylin Lane (ankle/IR) out and Terry McLaurin (hamstring) questionable, Jefferson will give the Commanders an experienced option behind Antonio Williams, Dyami Brown and Treylon Burks at wideout.
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Trey Lance QB | LAC
Chargers' Trey Lance: Placed on injured reserve
The Chargers placed Lance (groin) on injured reserve Saturday.
Lance has been on the Chargers' injury report since late September due to a groin issue. He suited up for each of the Chargers' last two games, but it appears his injury has regressed enough for him to warrant a stint on injured reserve. As such, Lance will be sidelined for at least four games, and the next time he can play is Week 10 against the Ravens on Sunday, Nov. 16. DJ Uiagalelei will be the Chargers' backup to Justin Herbert while Lance is sidelined.
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Storm Duck CB | MIA
Dolphins' Storm Duck: Out for Week 5
Duck (knee) has been downgraded to out for Sunday's game against the Bengals, David Furones of the South Florida Sun Sentinel reports.
Duck remains on the reserve/PUP list. After practicing in full this week, Duck will have a better chance to suit up in Week 7 following Miami's bye next week.