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Will Mallory TE | IND
Colts' Will Mallory: Healthy inactive
Mallory is inactive for Sunday's season opener against Miami due to a coach's decision, James Boyd of The Athletic reports.
Mallory had a good showing in training camp by all accounts, but he enters the season fourth on the depth chart at tight end and may not be active most game days. Mallory has receiving skills, but no tight end other than Tyler Warren may be a significant factor in the passing game.
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Kyler Murray QB | MIN
Cardinals' Kyler Murray: Suiting up Sunday despite illness
Murray (illness) is listed as active for Sunday's game at New Orleans, Darren Urban of the Cardinals' official site reports.
The Cardinals tacked on Murray to their Week 1 injury report Sunday morning due to an illness, but there was an expectation all along he'd be able to suit up. Whether or not he'll be able to make it through the entire game unscathed remains to be seen, but if Murray needs to step off the field at any point, Jacoby Brissett is on hand to direct Arizona's offense in such a scenario.
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D'Wayne Eskridge WR | MIA
Dolphins' Dee Eskridge: Cleared to play Week 1
Eskridge (concussion) is active for Sunday's game against the Colts.
Eskridge was limited in practice all week, but he has passed the league's five-step concussion protocol and will play in Sunday's regular-season opener in Indianapolis. Eskridge appeared in six regular-season games for the Dolphins in 2024 and logged three catches (on as many targets) for 44 yards while adding 146 kick return yards.
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Jermaine Burton WR | CIN
Bengals' Jermaine Burton: Surprise Week 1 scratch
Burton (coach's decision) is inactive for Sunday's game against the Browns, Paul Dehner Jr. of The Athletic reports.
Burton had a tumultuous rookie season but had gotten strong reviews for improvement throughout the offseason. That makes it particularly surprising that he'll be inactive for Week 1, though Charlie Jones and Mitchell Tinsley -- both active-- are set to serve as depth wide receivers and special teams contributors on Sunday.
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Riley Leonard QB | IND
Colts' Riley Leonard: Emergency QB for Week 1
Leonard (coach's decision) is inactive for Sunday's game against the Dolphins but will serve as the emergency third-string quarterback.
The rookie sixth-rounder will be allowed to see the field only if both Daniel Jones and Anthony Richardson were removed from Sunday's game due to injury. Leonard had a solid preseason, completing 34 of 56 passes for 345 yards, one touchdown and one interception across three games while adding seven carries for 58 yards.
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Raheem Mostert RB | LV
Raiders' Raheem Mostert: Not playing Week 1
Mostert (coach's decision) is a healthy inactive for Sunday's game against New England.
Mostert's inactive status comes as a surprise, as he's not known to be dealing with an injury and was listed as the Raiders' RB2 or RB3 on the team's initial Week 1 depth chart, per Vincent Bonsignore of the Las Vegas Review-Journal. With Mostert out of action, Las Vegas will go with Zamir White and Dylan Laube as the active running backs behind rookie starter Ashton Jeanty.
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Devin Culp TE | MIN
Buccaneers' Devin Culp: Healthy scratch Week 1
Culp (coach's decision) is inactive for Sunday's game against Atlanta.
With Cade Otton overcoming a lingering groin injury to play Week 1, Culp will observe Sunday's game in street clothes while Payne Durham and Ko Kieft serve in backup roles at tight end. Culp managed to make the Bucs' 53-man roster after a strong training camp, but the 2024 seventh-rounder is unlikely to see much playing time unless Otton, Durham or Kieft were to miss time. Culp's next chance to play is Week 2 against Houston on Monday, Sept. 15.
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Shedeur Sanders QB | CLE
Browns' Shedeur Sanders: Designated as emergency QB
Sanders (coach's decision) is inactive but designated as the emergency third quarterback for Sunday's game against the Bengals, Chris Easterling of the Akron Beacon Journal reports.
This move comes as little surprise, as coach Kevin Stefanski made clear that Sanders would begin the season third on the quarterback depth chart. Dillon Gabriel will serve as Joe Flacco's backup in Week 1.
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Tyler Goodson RB | DAL
Colts' Tyler Goodson: Inactive for Week 1
Goodson (elbow) is inactive for Sunday's season opener against the Dolphins.
After being limited at practice this week, Goodson approached the contest listed as questionable. With his regular-season debut on hold, DJ Giddens and Ulysses Bentley are available Sunday to handle backfield snaps that don't go to Jonathan Taylor. Goodson's next chance to see action will occur next weekend against the Broncos.
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Josh Williams RB | TB
Buccaneers' Josh Williams: Won't make NFL debut vs. Atlanta
Williams (coach's decision) is inactive for Sunday's game against the Falcons.
Williams managed to crack the Buccaneers' 53-man roster after a strong training camp, but the undrafted rookie out of LSU will be in street clothes for Week 1 as Tampa Bay goes with a three-man backfield of Bucky Irving, Rachaad White and Sean Tucker. Williams' next chance to make his NFL regular-season debut is Week 2 against the Texans on Monday, Sept. 15.