Santana isn't in the lineup for Wednesday's contest in Baltimore.

Santana will take a seat for the second straight game, as he's getting a chance to regroup while he's struggled to a .135/.224/.154 slash line to start the season. Jose Miranda will handle first base for Minnesota on Wednesday.

Duran started at designated hitter and went 1-for-4 with an RBI and a run scored in Tuesday's 4-2 loss to the Tigers.

Duran made a third consecutive start and has hit safely in all three, going 4-for-12. Prior to this run, Duran's playing time was sporadic. The injury to third baseman Josh Jung (thumb) created an opportunity, but the lefty-hitting Josh Smith has been the main beneficiary.

Harper went 2-for-4 with an RBI double and a two-run home run in Tuesday's 5-0 victory over Colorado.

Harper extended the Phillies lead to 3-0 with an opposite-field double off Austin Gomber in the sixth inning before capping the scoring with a two-run homer off Tyler Kinley in the eighth. Harper's gone 3-for-7 with four RBI in his last two contests after going just 2-for-27 in his previous seven games. Overall, he's slashing .215/.301/.462 with four home runs, 11 RBI and 14 runs scored through his first 17 games this season.

France isn't in the Mariners' lineup for Tuesday's game against the Reds.

France will get a day to regroup Tuesday after going 4-for-20 with three RBI and six strikeouts across his last five games. Luke Raley will take his place at first base and bat seventh.

Abreu is not in the lineup for Tuesday's game against Atlanta, Matt Kawahara of the Houston Chronicle reports.

Abreu is 2-for-30 over his past nine games and will head to the bench for Tuesday's contest. Jon Singleton will receive another start at first base, his third in Houston's past six games.

Wade is out of the lineup for Tuesday's game at Miami, Shayna Rubin of the San Francisco Chronicle reports.

Lefty Ryan Weathers is pitching Tuesday for the Marlins, so Wade will take a seat despite his 1.220 OPS over his past nine contests. Wilmer Flores will start at first base and bat second.

Vaughn is out of the lineup for Tuesday's game versus the Royals, Vinnie Duber of AllCHGO.com reports.

Vaughn started the first 16 games of the season but has a .457 OPS and is 1-for-16 over his past four contests. Gavin Sheets will start at first base as Eloy Jimenez (adductor) is back from the injured list and at designated hitter.

Mountcastle is out of the lineup for Tuesday's game against the Twins.

Mountcastle is off to a hot start this season with a .305/.368/.492 slash line through 15 games, but he'll take a seat for Tuesday's contest. Ryan O'Hearn will shift to first base while Adley Rutschman rests his legs as the designated hitter.

Cronenworth (calf) is absent from the lineup for Tuesday's game in Milwaukee.

Cronenworth was pulled from Monday's contest with calf tightness, so it's no surprise to see him sitting a day later. The good news is that he has not been placed on the injured list as the Padres brought up Matthew Batten as infield protection, projecting some apparent optimism that it's a day-to-day situation for Cronenworth. Jurickson Profar will handle first base Tuesday, while Jose Azocar will be in left field.

Sullivan was optioned to Triple-A El Paso by the Padres on Tuesday, Kevin Acee of The San Diego Union-Tribune reports.

Sullivan was around as a third catcher for a week but didn't receive any starts. He's being replaced on the roster by Matthew Batten.