Manager Torey Lovullo said after Wednesday's loss that Perdomo is day-to-day with right knee discomfort, Theo Mackie of The Arizona Republic reports.

Perdomo injured his knee rounding first base after reaching on an error during the bottom of the 10th inning. The team doesn't seem to be very concerned about his injury, and having a scheduled day off Thursday may allow the 24-year-old infielder to play again Friday against Atlanta without missing any games.

Perdomo was removed from Wednesday's game against the Yankees with an apparent knee injury, Theo Mackie of The Arizona Republic reports.

Perdomo reached base on an error during the bottom of the 10th inning but was limping as he ran toward second base. The Diamondbacks will take him into the clubhouse for a closer look and should have more information on his status after Wednesday's contest.

Cruz will start at shortstop and bat leadoff in Wednesday's game against the Nationals, Kevin Gorman of TribLive.com reports.

The Pirates faced five straight southpaws to begin the season, and the left-handed-hitting Cruz hit sixth twice, seventh twice and had one day off in those contests. With right-hander Trevor Williams taking the ball Wednesday, Cruz will be elevated to the top of the batting order.

Wade is out of the lineup for Wednesday's game against the Cardinals.

He'll remain on the bench with southpaw Zack Thompson on the hill for St. Louis, but the lefty-hitting Wade had already been withheld from the starting nine in two of the previous three games in which the Padres faced off against right-handers. After manning third base for each of San Diego's first three contests of the regular season, Wade's perch atop the depth chart seems to be loosening, with Graham Pauley and Eguy Rosario beginning to earn more playing time at his expense. All three players are likely to see their opportunities dwindle, however, once Manny Machado is cleared to play the hot corner on an everyday basis, as he remains limited to designated-hitter duties for now following October elbow surgery.

Tovar will start at shortstop and bat second in Wednesday's game against the Cubs, Luke Zahlmann of The Denver Gazette reports.

Tovar batted leadoff one game, but his other five starts this season came from the seventh spot in the order. Rockies manager Bud Black is shaking up his lineup a bit in hopes of jumpstarting an offense that's averaging just 2.7 runs per game amid a 1-5 start to the season.

Winn is not in the lineup for Wednesday's contest in San Diego, Jeff Jones of the Belleville News-Democrat reports.

It's a day off for Winn, who will yield to veteran Brandon Crawford at shortstop. Winn is 5-for-16 with one RBI and one stolen base in his first five games this season.

Merrill is out of the lineup for Wednesday's game against the Cardinals, Jeff Sanders of The San Diego Union-Tribune reports.

The Cardinals are rolling out southpaw Zack Thompson, so the left-handed hitting Merrill will take a seat. The Padres will go with Jose Azocar in center field.

Arcia is out of the lineup for Wednesday's game against the White Sox.

Arcia will head to the bench in what appears to be routine maintenance for a day game after a night game. Luis Guillorme will step in at shortstop for Arcia, who has gone 9-for-20 with four doubles and one walk while plating two runs and scoring twice through Atlanta's first five contests of the season.

Betts went 2-for-5 with a solo home run and an additional run scored during Tuesday's win over the Giants.

Betts' bat continues to be one of the best in baseball, as he mashed his league-leading fifth home run of the campaign. He sits comfortably atop the league in hits (15) with the next-closest players a full three hits behind, and he has 14 more total bases than any other player. While his ridiculous .500/.605/1.167 slash line is certain to regress at some point, fantasy managers have to be thrilled with what they're getting from the six-time All-Star early on.

Perdomo went 2-for-4 with a run scored in Tuesday's 7-0 win over the Yankees.

It's been a quiet start for Perdomo, who is 6-for-20 with a double, an RBI and three runs scored through six games. Not bad, but nothing eye-popping. After batting .195 during his rookie season in 2022, the shortstop adjusted to the grind of MLB in 2023 (.246 AVG, .712 OPS), and Perdomo looks to continue that trajectory this season.