Mahomes completed 29 of 45 passes for 276 yards and a touchdown with an interception in Sunday's 22-19 loss to the Broncos. He added three rushing yards on one carry.

Even with Patrick Surtain (pectoral) still sidelined, Mahomes had trouble breaking down the Denver secondary, with his lone TD pass coming in the fourth quarter on a play in which Travis Kelce did most of the work. The star QB did at least extend his streak of games with 250-plus passing yards to seven, a stretch in which he's posted a 15:5 TD:INT, 66.8 percent completion rate and 7.7 YPA. Mahomes will try to get back on track, and revive Kansas City's suddenly fading playoff hopes, at home in Week 12 against the Colts.

Lawrence completed 14 of 22 passes for 153 yards with a touchdown and an interception while rushing five times for nine yards and another score in the Jaguars' 35-6 win over the Chargers on Sunday.

Lawrence put together another lackluster stat line, but he leveraged the strong work of his ground game and defense for an easy win. Both of the fourth-year signal-caller's touchdowns came from one yard out, as he recorded a short scoring run with just under eight minutes remaining in the third quarter and had a short scoring toss to Tim Patrick early in the final period. Lawrence has now been under 200 passing yards in consecutive games and on four occasions overall this season, and he'll next face off with the inconsistent Cardinals defense in a Week 12 road matchup.

Darnold completed 29 of 44 pass attempts for 279 yards, no touchdowns and four interceptions while rushing for 11 yards on two carries in Sunday's 21-19 loss to the Rams.

Darnold failed to bounce back from last week's three-pick effort, instead lowering the bar by throwing four interceptions for the first time since 2019 during his infamous run with the Jets. It would be unfair to compare that version of the signal-caller to the improved franchise quarterback he developed into over the years, but Darnold is developing a concerning trend of losing his composure in big games. Notably, the last time he faced the Rams -- as a member of the Vikings in 2024 -- he fell flat while committing two turnovers in a playoff loss. The 28-year-old's horrid two-game stretch brings him to 17 touchdowns and 10 interceptions following a red-hot start to the fantasy campaign. Darnold's gaudy passing totals (2,541 yards in 10 starts) keep him in the starting conversation as a fantasy option against the Titans next Sunday.

Penix (knee) is believed to have aggravated a previous knee injury during Sunday's 30-27 overtime loss to the Panthers, and there is concern that he could miss additional time, Ian Rapoport and Tom Pelissero of NFL Network report.

Penix exited in the third quarter of Sunday's loss, and Kirk Cousins finished out the game in relief. Cousins filled in when Penix sat out Atlanta's 34-10 loss to the Dolphins due to a bone bruise in his knee Week 8. If Penix misses additional action as feared, Cousins would start Week 12 against the Saints. Penix is set for additional testing on his injury.

Brissett completed 47 of 57 passes for 452 yards, two touchdowns and two interceptions and rushed twice for minus-2 yards during Sunday's 41-22 loss to the 49ers.

Working without No. 1 WR Marvin Harrison (concussion) on Sunday, Brissett set an NFL regular-season record for a single game with his 47 completions, helping fuel a pair of 100-yard receiving efforts from WR Michael Wilson (15-185-0 on 18 targets) and TE Trey McBride (10-115-1 on 11 targets). The pass-heavy approach from the Cardinals likely was spurred by being down double-digit points as soon as the 13:39 mark of the second quarter, and the closest margin after that point was nine points before the 49ers tacked on a pair of field goals in the last 1:01 of the first half. In five starts in place of Kyler Murray (foot, IR), Brissett has averaged 314 yards per game to go with a 10:3 TD:INT on 67 percent passing. Brissett's next chance to continue leading Arizona's offense is next Sunday versus the Jaguars.

Purdy (toe) completed 19 of 26 pass attempts for 200 yards and three touchdowns while losing seven yards on his only carry in Sunday's 41-22 win over the Cardinals.

Purdy made a triumphant return from a turf toe injury that cost the signal-caller six weeks of action, tossing a trio of touchdowns with no turnovers in a decisive victory over a division opponent. The 25-year-old connected in the end zone with top weapons Christian McCaffrey and George Kittle (twice) as San Francisco's offense looked as healthy as it has since Week 1. Purdy had thrown as many touchdowns (four) as interceptions over his previous two starts this season, neither of which he exited at full strength. Assuming that he escaped Sunday's win with a clean bill of health, fantasy managers can feel comfortable again starting Purdy against the Panthers on Monday Night Football in Week 12.

Herbert completed 10 of 18 passes for 81 yards with no touchdowns and one interception while adding three rushes for 21 yards in the Chargers' 35-6 loss to the Jaguars on Sunday.

The sixth-year pro put together a performance that was about as poor as his numbers indicated, with Herbert finishing with a career-low yardage total. Herbert was sacked just twice but appeared to be under constant duress, and he failed to throw a touchdown pass for the first time all season before being pulled for Trey Lance in the fourth quarter. The Chargers will now have a Week 12 bye to regroup before returning to action in a Week 13 home matchup against the Raiders on Sunday, Nov. 30.

Stafford completed 15 of 28 passes for 130 yards and two touchdowns in Sunday's 21-19 win over the Seahawks.

Stafford's yardage total dipped as both pass defenses stepped up in the battle for first place in the NFC West, but he avoided mistakes and improved his TD:INT to 22:0 over the past seven starts, while the Rams picked off Sam Darnold four times. Stafford threw a one-yard touchdown pass to Davante Adams in the first quarter and a six-yard touchdown pass to Colby Parkinson in the fourth quarter. The Rams will likely lean more on Stafford's arm in Week 12 against a beatable Buccaneers secondary that just allowed six total touchdowns to fellow potential MVP candidate Josh Allen.

Howell (coach's decision) is inactive but operating as the Eagles' emergency third quarterback versus the Lions on Sunday Night Football.

Howell will once again operate as the No. 3 QB in Week 11, and he'd only enter the game if Jalen Hurts and Tanner McKee are forced out. The 25-year-old has yet to appear in a regular-season contest this year.

Mayfield completed 16 of 28 passes for 173 yards with one touchdown and one interception while adding five carries for 39 yards and another score in the Buccaneers' 44-32 loss to the Bills on Sunday. He also lost a fumble.

Mayfield fought hard in trademark fashion all afternoon, often taking matters into his own hands when an aggressive Bills defense applied pressure. Buffalo's talented secondary did limit Mayfield to his third lowest passing yardage tally of the campaign. Mayfield connected with Sean Tucker for his one touchdown pass from 28 yards out, a play he preceded with a four-yard scoring run early in the second quarter. Mayfield and the Bucs next set their sights on a Week 12 road showdown against the Rams next Sunday night.