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Derrick Henry RB | BAL
Ravens' Derrick Henry: Over 100 rushing yards with receiving TD
Henry rushed 24 times for 102 yards while catching one of two targets for an 18-yard touchdown in Sunday's 30-23 overtime win over the Falcons. He also ran in a two-point conversion.
Henry unsurprisingly worked as the focal point of Baltimore's offense in the absence of Lamar Jackson (ankle). The star running back pulled the Ravens within two points with his 18-yard touchdown catch in the third quarter. Baltimore's two-point conversion attempt after that touchdown failed, but Henry took matters into his own hands to convert a game-tying two-point conversion out of the wildcat formation with 40 seconds left in the fourth quarter. He then tacked on 32 rushing yards on Baltimore's touchdown drive in OT to top the century mark on the ground for the first time since Week 1. Henry has opened his 11th NFL season with a five-game touchdown streak, producing seven rushing touchdowns and one receiving score ahead of a Week 6 trip to Cleveland.
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Tyjae Spears RB | TEN
Titans' Tyjae Spears: Nine catches in defeat
Spears rushed twice for no gain and lost a fumble while catching all nine of his targets for 28 yards during Sunday's 26-3 loss to the Texans.
Spears put the ball on the ground on his first carry of the day in the first quarter, and the fumble was recovered by Texans cornerback Jalen Pitre. The running back only had one more rush on the day, but he was able to make his mark as a pass-catcher, leading the team while reeling in a career-high nine passes. Spears has now turned 17 carries into 65 yards while catching 14 of 16 targets for 68 yards over five contests this season.
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Bijan Robinson RB | ATL
Falcons' Bijan Robinson: Posts 118 scrimmage yards in OT loss
Robinson rushed 17 times for 86 yards while catching four of seven targets for 32 yards in Sunday's 30-23 overtime loss to the Ravens.
Robinson was held without a touchdown after scoring four times over the previous two games, but he managed to top 100 scrimmage yards for the fourth time in five games. The star running back was far more effective than backup Brian Robinson, who also had four touchdowns over the previous two games but turned seven carries and one target into just 16 yards against the Ravens. Bijan has racked up 732 scrimmage yards and five total TDs heading into a Week 6 home game against the Bears. Michael Penix (ribs) was hurt late in Sunday night's loss to Baltimore, so it remains to be seen whether Penix or Tua Tagovailoa will start under center for Atlanta against Chicago.
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Chris Rodriguez Jr. RB | JAC
Jaguars' Chris Rodriguez: Two rushes in win
Rodriguez rushed twice for five yards and caught his only target for six yards during Sunday's 19-17 win over Philadelphia.
Rodriguez was scarcely used in Week 5, logging his fewest carries in a game this season. Starting running back Bhayshul Tuten turned 22 carries into 72 yards, and he's clearly the preferred option over Rodriguez in the backfield, regardless of circumstance. Over five games this season, Rodriguez has rushed 28 times for 113 yards and two touchdowns while catching one pass for six yards.
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MarShawn Lloyd RB | GB
Packers' MarShawn Lloyd: Scores twice in dominant win
Lloyd rushed 10 times for 31 yards and two touchdowns while catching one of two targets for six yards during Sunday's 31-7 win over the Bears.
Lloyd was able to open the second quarter with a 10-yard touchdown run before later adding a four-yard score in the fourth quarter. The running back's 10 carries were his most since logging 13 rushes for 37 yards in Week 1 versus Minnesota. Lloyd has now compiled 112 rushing yards on 40 carries and two touchdowns while reeling in 10 of 13 targets for 55 yards and a score over five games to open the 2026 season while operating as Green Bay's primary option in the backfield with Josh Jacobs (personal) on the Commissioner's Exempt List.
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Dylan Laube RB | LV
Raiders' Dylan Laube: Finds paydirt in blowout loss
Laube rushed four times for nine yards and a touchdown while also reeling in all three of his targets for 16 yards during Sunday's 45-17 loss to New England.
Laube finished second on the team in carries behind starting running back Ashton Jeanty (10). Laube was able to notch his first career rushing touchdown in the fourth quarter, punching it in from two yards out. The running back also added 69 kickoff-return yards in the contest. Laube will likely remain third in the pecking order behind Jeanty and rookie Mike Washington heading into Week 6, giving him little to no fantasy value.
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Kimani Vidal RB | LAC
Chargers' Kimani Vidal: Aonther TD in Week 5
Vidal tallied eight carries for 57 yards and one touchdown, one catch (on two targets) for minus-1 yard and returned three kicks for 75 yards during Sunday's 23-17 defeat to the Broncos.
After opening the season with no touches through the first two games -- and just two in Week 3 -- Vidal has taken full advantage of his 16 over the last two contests, turning them into 92 yards from scrimmage and two TDs. All three of the Chargers' running backs got in the mix Sunday, with Omarion Hampton earning 15 touches and Keaton Mitchell getting six, but Vidal was the only one of the trio with an end-zone visit. Considering his recent success, Vidal appears likely to hold on to a regular role next Sunday at Kansas City.
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Rachaad White RB | WAS
Commanders' Rachaad White: Seven touches in return
White (shoulder) rushed seven times for 18 yards while catching his only target for two yards in Sunday's 27-27 tie against the Giants.
White recorded 20 scrimmage yards on seven touches in his return from a one-game absence due to a shoulder injury. Jacory Croskey-Merritt led Washington's running backs with 11 carries for 82 yards and a touchdown, while White and Austin Ekeler each drew one target out of the backfield. Ekeler's return to Washington could prove problematic for White, as the two veteran running backs could split passing-down work while Croskey-Merritt continues to get most of the carries. White could get more opportunities if the Commanders are forced to play catch-up against the 5-0 49ers in Week 6.
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Rhamondre Stevenson RB | NE
Patriots' Rhamondre Stevenson: Punches in TD in win over Vegas
Stevenson carried the ball 13 times for 64 yards and a touchdown and caught all three of his targets for 21 yards in Sunday's 45-17 rout of the Raiders.
There was some question whether Stevenson would even be active for this one after a knee issue limited his practice participation during the week, but the veteran was the clear top option in the Patriots' backfield as TreVeyon Henderson managed just 38 scrimmage yards on five touches. Stevenson's longest gain went for 20 yards en route to a season high in rushing yards, and he punched in a five-yard TD in the first quarter that put New England in the lead for good at 14-7. Stevenson will look to keep rolling in a Week 6 tilt against the Jets.
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RJ Harvey RB | DEN
Broncos' RJ Harvey: Earns only target in Week 5
Harvey notched three carries for seven yards and didn't haul in his only target during Sunday's 23-17 road win versus the Chargers.
After being targeted a whopping 17 times over the previous two games, Harvey experienced a change in fortunes Sunday as no Bronco earned more than WR jaylen Waddle's five looks from QB Bo Nix. Harvey hasn't been able to get anything going on the ground this season (3.7 YPC) in his four appearances while Dobbins has earned the more consistent workload (13.8 touches per game), leaving the former a distant second in the pecking order out of Denver's backfield.