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Justin Herbert QB | LAC
Chargers' Justin Herbert: Two more turnovers in Week 5
Herbert completed 14 of 24 passes for 121 yards, one touchdown and one interception, reeled off 54 yards on six carries and fumbled twice (one lost) during Sunday's 23-17 loss to the Broncos.
Herbert's season-low number of pass attempts amounted to by far his lowest yardage total through the air through five contests this season. He also turned over the ball two times, which resulted in two late made field goals for Denver (i.e. the margin of defeat) and bringing his total on the campaign to nine (seven INTs, two lost fumbles). Granted, Herbert was working without WR Quentin Johnston (chest, inactive), while Ladd McConkey (foot) was active but doesn't appear to have played a snap, so the deck was stacked against him versus a tough defense. Herbert's next chance to get right is next Sunday versus the 4-0 Chiefs.
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Samaje Perine RB | CIN
Bengals' Samaje Perine: Reaches end zone in victory
Perine rushed 14 times for 68 yards while catching both of his targets for 10 yards and a touchdown during Sunday's 31-24 win over Miami.
Perine surprisingly logged one more carry than starting running back Chase Brown (13) in the contest. Additionally, although he saw two fewer targets than Brown, Perine was able to reach paydirt in the second quarter, reeling in a six-yard touchdown pass from Joe Burrow. Perine remains a highly valuable handcuff option for fantasy managers with Chase Brown on their rosters. Through five games, the 31-year-old has rushed 27 times for 110 yards while reeling in seven of 10 targets for 61 yards and a score.
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Trey McBride TE | ARI
Cardinals' Trey McBride: Busy as usual in Week 5 loss
McBride brought in nine of 10 targets for 66 yards and a touchdown in the Cardinals' 45-21 loss to the Lions on Sunday.
McBride was in the familiar position of leading the Cardinals in receptions and targets, and he was narrowly second to Kendrick Bourne in receiving yards. The star tight end's touchdown reception was also a thing of beauty despite the fact it came when the game was completely out of reach, as McBride somehow secured the pass inbounds after tapping it twice to himself while swarmed by two defenders. McBride already has three nine-catch tallies in the first five games of the season, and he's also opened the campaign with five consecutive double-digit target tallies. McBride already has 42 receptions in 2026, putting him well on pace for a third straight 100-catch season heading into a Week 6 home matchup against the Rams next Sunday.
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Omarion Hampton RB | LAC
Chargers' Omarion Hampton: Musters 39 total yards in Week 5
Hampton turned 14 carries into 33 yards and one target into a six-yard catch during Sunday's 23-17 loss to the Broncos.
Hampton has found room to run in the Chargers' mostly stagnant offense difficult to come by so far this season, averaging 3.7 YPC through five games after going for 4.4 as a rookie in 2025. And on Sunday in particular, he had to contend with fellow RBs Kimani Vidal (nine touches) and Keaton Mitchell (six) mixing into the action a decent amount. Due to ceding those reps to his backfield mates, Hampton's weekly ceiling doesn't appear to be as high as it may have seemed heading into the campaign.
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Amon-Ra St. Brown WR | DET
Lions' Amon-Ra St. Brown: Six catches in Week 5 win
St. Brown secured six of 11 targets for 69 yards and committed two fumbles that remained with Detroit in the Lions' 45-21 win over the Cardinals on Sunday.
St. Brown fell below his usual lofty standards with his numbers, but the star receiver still finished with team-high reception and target totals, while also slotting in as the runner-up in receiving yards. St. Brown remains as integral a component of the Lions' air attack as ever, as he now has back-to-back 11-target games and has already seen 57 passes come his way overall in the first five contests of the campaign. St. Brown has turned those opportunities into a 37-372-5 line, and he'll be looking to snap a two-game touchdown drought when the Lions return to action in a NFC North home clash against the Packers on Sunday, Oct. 25 following a Week 6 bye.
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Kyle Williams WR | NE
Patriots' Kyle Williams: Finds paydirt in blowout win
Williams caught all three of his targets for 91 yards and a touchdown while also adding three kick returns for 71 yards during Sunday's 45-17 win over the Raiders.
Williams led the team in receiving yards during the victory, most notably reeling in a 34-yard touchdown pass from Drake Maye in the second quarter. The wide receiver has now caught five of 10 targets for 135 yards and a touchdown while also compiling 344 yards as a kick returner over five contests to open the 2026 campaign.
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Pat Freiermuth TE | PIT
Steelers' Pat Freiermuth: Finds end zone twice in win over Indy
Freiermuth caught five of seven targets for 44 yards and two touchdowns in Sunday's 34-22 win over the Colts. He added one yard on his lone carry.
The veteran tight end connected with Aaron Rodgers on a one-yard score in the second quarter and a 17-yard strike in the fourth. Freiermuth is up to four touchdowns through five games to begin the season, already matching his total over 17 regular-season contests in 2025, and his 19 catches has him on pace to match the career-high 65 passes he hauled in during 2024. Freiermuth will look to keep rolling in a Week 6 road trip to Tampa Bay.
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Mike Evans WR | SF
49ers' Mike Evans: First 100-yard receiving game with SF
Evans caught seven of 10 targets for 113 yards and a touchdown in Sunday's 32-29 win over the Seahawks. He also caught a successful two-point conversion.
Evans opened the scoring with a two-yard touchdown catch, one play after a drive-extending 13-yard reception on third-and-7. He continues to work as the leader of San Francisco's banged-up passing game, which lost Deebo Samuel (hamstring) in the third quarter. George Kittle, who was playing through an illness, finished a distant second on the team with 24 receiving yards. Evans' two-point conversion extended San Francisco's lead to three points with 11:02 left in the fourth quarter, and both teams tacked on a field goal from there as the 49ers improved to 5-0 heading into a Week 6 home game against the Commanders on MNF.
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Jahmyr Gibbs RB | DET
Lions' Jahmyr Gibbs: Eclipses 200 scrimmage yards in win
Gibbs rushed 25 times for 151 yards and two touchdowns while bringing in five of six targets for 56 yards in the Lions' 45-21 win over the Cardinals on Sunday.
Gibbs, and the Lions' offense as a whole, had a somewhat quiet start to the game, but the star running back soon began breaking through against the Cardinals defense and ultimately turned in another dominant performance. Gibbs recorded his first touchdown from one yard out early in the second quarter and went on to add a three-yard scoring rush with just over five minutes remaining to seal the high-scoring victory. Gibbs' finished with his second-highest rushing yardage total of the season, and the multi-touchdown tally on the ground was already his third of the campaign. The 2023 first-round pick is up to 504 rushing yards, 243 receiving yards and nine total touchdowns heading into a Week 7 divisional home matchup against the Packers on Sunday, Oct. 25 following a Week 6 bye.
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DK Metcalf WR | PIT
Steelers' DK Metcalf: Quiet day in Week 5 win
Metcalf caught three of four targets for 12 yards in Sunday's 34-22 win over the Colts.
The veteran wideout didn't make much impact as a pass catcher, but his blocking played a big role on a pair of long Jaylen Warren touchdowns. It was still a disappointing showing from Metcalf after he popped for a 5-115-0 line the week before, but he remains Aaron Rodgers' top downfield threat with a 19-225-1 line on 37 targets through five games. He'll likely be a feast or famine option once again in Week 6 against the Buccaneers.