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Freddy Fermin C | SD
Padres' Freddy Fermin: Out of Wednesday's lineup
Fermin is out of the lineup for Wednesday's game against the Phillies.
Fermin has yet to pick up a hit since May 14 while in the midst of an 0-for-26 slide at the plate, and he will take a seat Wednesday after starting five of the previous six games. Rodolfo Duran will replace him at catcher and bat ninth in the order.
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Rhett Lowder SP | CIN
Reds' Rhett Lowder: Confirmed for start Sunday
Reds manager Terry Francona confirmed Wednesday that Lowder (shoulder) will be reinstated from the injured list to start Sunday's game in St. Louis, Charlie Clifford of NBC 5 Cincinnati reports.
Francona indicated previously that Lowder would rejoin the Reds' rotation for Sunday's series finale as long as he got through Tuesday's rehab start at Triple-A Louisville without any hiccups. That happened, as the righty had an 8:0 K:BB over five innings while yielding three runs. Lowder threw 70 pitches on Tuesday, so he will not be fully stretched out against the Cardinals. The right-hander has been sidelined since early May due to right shoulder discomfort.
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J.T. Realmuto C | PHI
Phillies' J.T. Realmuto: Back in Philadelphia lineup
Realmuto (wrist) will start at catcher and bat seventh in Wednesday's game against the Padres.
Realmuto missed Tuesday's series opener after being hit on the left wrist by a pitch versus the Dodgers on Sunday, but he's back in there following a one-game absence. The veteran catcher enters play Wednesday having slashed only .192/.259/.260 in 22 games since the start of May.
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Cal Raleigh C | SEA
Mariners' Cal Raleigh: Starting rehab assignment Sunday
Raleigh (oblique) will begin a rehab assignment with High-A Everett on Sunday, Daniel Kramer of MLB.com reports.
Raleigh will move up to Triple-A Tacoma on Tuesday and will continue his rehab assignment there for the rest of next week before the Mariners evaluate him for a return to the active roster. That sets Raleigh up to return to the Seattle lineup June 16 for the beginning of a homestand, assuming all goes well. He's been out since mid-May due to a right oblique strain.
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Maikel Garcia 3B | KC
Royals' Maikel Garcia: Held out again Wednesday
Garcia (hamstring) remains out of the lineup for Wednesday's game in Cincinnati.
This marks Garcia's fourth consecutive absence from the starting lineup as he continues to deal with a right hamstring issue. The Royals have held off on putting Garcia on the 10-day injured list, but a move will have to be made soon if he's not game-ready in a hurry. Nick Loftin is filling in again at third base Wednesday in Garcia's stead.
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Samad Taylor LF | SD
Padres' Samad Taylor: Added to MLB roster
The Padres selected Taylor's contract from Triple-A El Paso on Wednesday.
Taylor was elevated to the big-league club after slashing .319/.406/.500 with the Triple-A squad. The 25-year-old was most recently in the majors with Seattle in 2025, though he recorded just eight at-bats. Taylor will replace Nick Castellanos on the active roster after the latter was designated for assignment.
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Nick Castellanos RF | SD
Padres' Nick Castellanos: DFA'd by San Diego
The Padres designated Castellanos for assignment Wednesday.
The Padres gladly scooped Castellanos up for the league minimum in February after he was cut loose by the Phillies, but he simply didn't hit enough to justify a roster spot, slashing only .191/.221/.339 with four home runs and a 5:34 BB:K over 39 contests. The 34-year-old Castellanos could be hard-pressed to find another major-league contract at this point.
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Colin Holderman RP | CLE
Guardians' Colin Holderman: Picks up fourth win
Holderman (4-1) got the win after allowing a hit and no walks in a scoreless inning while striking out two in a 9-4 win over the Yankees on Tuesday.
Holderman entered in the bottom of the fifth, striking out both Amed Rosario and Jazz Chisholm, and kept Cleveland's 5-4 lead intact. Coming off one of his worst appearances of the season Sunday -- when he allowed two earned runs to Boston in just one-third of an inning -- Holderman bounced back in a big way Tuesday. The 30-year-old has a 2.05 ERA, 0.82 WHIP and 25:6 K:BB through 22 innings in his first season with Cleveland.
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Alex Cook RP | TB
Rays' Alex Cook: Back from intercostal strain
Triple-A Durham activated Cook (intercostal) from the 7-day injured list May 23.
Cook, after missing a little over two weeks of action due to an intercostal strain, has turned in back-to-back scoreless outings since returning to the mound. The 25-year-old right-hander has made 13 appearances (three starts) at the Triple-A level in 2026, posting a 5.02 ERA, 1.19 WHIP and 16:7 K:BB covering 14.1 innings.
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Jeremiah Estrada RP | SD
Padres' Jeremiah Estrada: Responsible for loss
Estrada (2-2) picked up the loss after giving up the eventual game-winning run in a 3-2 loss to Philadelphia on Tuesday.
Estrada entered the game in the bottom of the sixth with the score tied at 2-2. The 27-year-old allowed Bryce Harper to cross home plate as the go-ahead run as a result of an Alec Bohm double play, limiting the damage at just one run. Estrada has given up two earned runs over his last two appearances after previously pitching 4.2 scoreless innings. The right-hander now sports a 3.48 ERA, 1.11 WHIP and 23:10 K:BB through 20.2 innings this season.