Williams completed 25 of 42 pass attempts for 330 yards and two touchdowns while adding 18 rushing yards on five attempts in Sunday's 42-38 loss to San Francisco.

Williams was engaged in a classic shootout with 49ers QB Brock Purdy (303 yards, five total TDs) with both signal-callers cracking the 300-yard mark while tossing multiple touchdowns. For Williams, it was the first time through 16 starts in 2025 in which he eclipsed 300 passing yards in a single game. The improving sophomore had an opportunity to throw a third score and win the game in the closing moments of Sunday Night Football, only to watch his pass come up a yard short of a fully extended Luther Burden (leg) in the end zone as time expired. Williams has now thrown multiple touchdown passes in four consecutive starts with an improved yardage total in each game. His recent hot streak coupled with a soft matchup against the Lions makes Williams a strong fantasy play in Week 18.

Purdy completed 24 of 33 pass attempts for 303 yards, three touchdowns and one interception while taking six carries for 28 yards and two touchdowns in Sunday's 42-38 win over Chicago.

Purdy followed up his career game against the Colts on Monday Night Football in Week 16 (295 yards, five TD passes) by dropping another five-score bonanza on the Bears in a second consecutive primetime victory. The 25-year-old looked Mahomes-esque in the third quarter while dancing through multiple defenders behind the line of scrimmage before ultimately dumping the ball off to an open Kyle Juszczyk for the second of three touchdown strikes. Purdy's improved movement and gaudy passing numbers since the 49ers' Week 14 bye (297.7 passing yards/game with 15 total TDs in three starts) indicate that the signal-caller is finally fully healed from the turf toe injury that derailed the earlier portions of his 2025 campaign. With the 12-4 49ers needing just one win to secure the No. 1 seed in the NFC and a first-round bye, fantasy managers can expect to see Purdy's best against the Seahawks in Week 18.

Pickett completed both of his passes for 16 yards in Sunday's 34-10 loss to the Giants.

Geno Smith exited the game with an ankle injury early in the fourth quarter, with Pickett relieving him for the Raiders' final possession. Pickett completed short passes of 11 and five yards, though the drive resulted in a turnover on downs. Following the game, head coach Pete Carroll said Smith suffered a high-ankle sprain, setting Pickett up for a Week 18 start against the Chiefs, per Ryan McFadden of ESPN.com.

Dart completed 22 of 30 passes for 207 yards, no touchdowns and no interceptions in Sunday's 34-10 win over the Raiders. He added nine rushes for 48 yards and two touchdowns.

Dart had a rough showing in Week 16, but he bounced back in an advantageous matchup. He connected with both Wan'Dale Robinson and Darius Slayton for long gains of 36, 21, 17 and 15 yards to average 6.9 yards per attempt -- his highest mark in his last three starts. Equally encouraging was Dart's aggressiveness with his legs, which included rushing scores of 12 and two yards. He should have the chance to end his rookie season well in a Week 18 matchup against Dallas.

Hurts completed 13 of 27 pass attempts for 110 yards and a touchdown while gaining five yards on three carries in Sunday's 13-12 win over Buffalo.

Hurts struggled with his accuracy in wet conditions Sunday, completing less than 50 percent of his passes in a game for the first time this season. The dual-threat quarterback's 115 yards from scrimmage also represented his lowest total through 16 starts in 2025. Hurts salvaged what would have been a true stinker of a fantasy performance by tossing his career-best 25th touchdown pass to TE Dallas Goedert in the first quarter of Sunday's narrow victory. The Eagles will look to finish the regular season on a high note when Hurts leads the offense against the Commanders in Week 18.

Allen completed 23 of 35 pass attempts for 262 yards while rushing seven times for 27 yards and two touchdowns with one fumble lost in Sunday's 13-12 loss to the Eagles.

Philadelphia's staunch defense held Buffalo's offense scoreless through three quarters before Allen put the team on his back and punched in a pair of late scores to give his team life. A blocked PAT after the first touchdown created a tough decision for head coach Sean McDermott on the ensuing point-after scenario with the game and AFC East division title hopes on the line. The Bills declined the opportunity to send the game to overtime, instead opting to go for two following Allen's second trip to the end zone. There wasn't enough magic left in the normally clutch superstar's tank when his final pass of the game sailed out of the reach of WR Khalil Shakir as the Eagles took the field to celebrate the narrow win. Allen performed well on an individual level despite playing through a minor foot injury Sunday. The 29-year-old threw for his most yards since Week 11 while posting multiple rushing scores for the fifth time this season. The loss drops Buffalo down to the AFC's seventh seed as the team prepares to finish the regular season against the Jets in Week 18.

Head coach Pete Carroll said after Sunday's 34-10 loss to the Giants that Smith has a high-ankle sprain, Ryan McFadden of ESPN.com reports.

Smith exited in the second half due to an ankle injury, which has since been determined to be a high-ankle sprain. Such injuries typically recover multiple weeks to recover from, so Smith is unlikely to be available for the regular-season finale against the Chiefs. Kenny Pickett would be in line to start in Week 18 if Smith is unavailable. The Raiders would secure the first overall pick in the 2026 NFL Draft with a loss to Kansas City.

Smith (ankle) has been ruled out for the remainder of Sunday's contest against the Giants.

Smith was initially listed as questionable after injuring his ankle early in the fourth quarter, but he's now been ruled out with under two minutes remaining in Sunday's contest and Las Vegas down 34-10. If Smith's ankle injury impacts his availability for the Raiders' regular-season finale against Kansas City in Week 18, Kenny Pickett will stand to close out the team's 2025 campaign under center.

Rivers completed 17 of 30 passes for 147 yards, one touchdown and one interception in Sunday's 23-17 loss to the Jaguars.

Rivers drew his third consecutive start and faced a tough Jacksonville defense. He managed to complete six passes that went for double-digit yardage and also chipped in a five-yard touchdown completion to Mo Alie-Cox. However, Rivers ultimately averaged only 4.9 yards per attempt while also throwing a costly pick midway through the fourth quarter that ultimately played a big part in the team's loss. With the Colts eliminated from playoff contention, it's unclear if Rivers will start in Week 18 against the Texans.

Cook completed 19 of 33 passes for 152 yards, no touchdowns and one interception in Sunday's 42-10 loss to the Patriots. He also rushed twice for one yard.

Cook saw his career TD:INT drop to 1:7 through four regular-season appearances (three starts). The undrafted rookie has looked overmatched at the NFL level, but the 3-13 Jets will likely give Cook one more chance to start in Week 18 against the Bills before reassessing their quarterback room in the offseason. The Jets' only touchdown in the lopsided loss to New England came on a 59-yard run by Breece Hall (knee) in the fourth quarter.