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Michael Penix Jr. QB | ATL
Falcons' Michael Penix: Could play in Week 2
Penix (knee) was listed as a full participant in Wednesday's practice, Daniel Flick of The Atlanta Journal-Constitution reports.
Penix practiced fully from Wednesday through Friday last week and ultimately was inactive for Week 1, so he is not a lock to suit up for Week 2 just yet. However -- per the same source above -- he shared the first-team work with Cooper Rush on Wednesday, and -- via Marc Raimondi of ESPN.com -- Penix himself indicated he could take the field Sunday. It likely will not be known for a day or two who will start at quarterback for the Falcons in Week 2, but at the least Penix is in the mix.
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Zay Flowers WR | BAL
Ravens' Zay Flowers: Misses Wednesday's practice
Flowers (hamstring) was listed as a non-participant for Wednesday's practice.
Flowers aggravated a hamstring issue from the preseason during Sunday's win over the Colts. He had piled up a career-high 150 yards in the first half but did not return to action after the aggravation. Coach Jesse Minter called Flowers day-to-day earlier Wednesday. Flowers' next chance to practice will come Thursday, but at this stage his status for Week 2 is murky at best. Baltimore's receiving depth is being tested early as rookie Ja'Kobi Lane (wrist) is on injured reserve after undergoing surgery.
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Alec Pierce WR | IND
Colts' Alec Pierce: Practices fully Wednesday
Pierce (hand/wrist) fully participated in Wednesday's practice, Kevin Bowen of 107.5 The Fan Indianapolis reports.
Pierce was listed on the injury report with the heel injury he dealt with previously and not the wrist issue he picked up in Week 1, but neither prevented him from getting in a full session Wednesday. As such, consider Pierce in the clear for his team's Week 2 matchup with the Chiefs.
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Aaron Jones RB | MIN
Vikings' Aaron Jones: Bigger role on tap
Jones projects to have a bigger role in the coming weeks with Jordan Mason (thumb) on short-term injured reserve, Alec Lewis of The Athletic reports.
Jones impressed in Week 1 with a touchdown but played only 30 snaps, as Jordan Mason ate up a decent amount of reps as well. With Mason out for at least four weeks, Jones projects to lead the backfield while DeeJay Dallas, Demond Claiborne and Jerome Ford serve as depth options.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Good to go for Week 2
Kamara (knee) was a full participant in Wednesday's practice, Katherine Terrell of ESPN.com reports.
New Orleans' backfield will get a boost in Week 2 with Kamara back in the mix after missing the season opener with a knee injury. The veteran injured his knee late in the preseason and returned to practice ahead of Week 1 but was not yet ready to give it a go. His full practice Wednesday points to Kamara being available for Sunday's game against the Ravens.
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TreVeyon Henderson RB | NE
Patriots' TreVeyon Henderson: Full practice Wednesday
Henderson (ankle) was a full participant in Wednesday's practice.
This is a big development for Henderson after his ankle injury kept him out of the season opener. He was a full-go in Wednesday's session, which bodes well for him making his 2026 debut Sunday against the Steelers. The Patriots struggled to run the ball in his absence against the Seahawks, recording just 3.9 yards per carry as a team. Rhamondre Stevenson and Corey Kiner mustered just 62 yards on 24 carries.
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RJ Harvey RB | DEN
Broncos' RJ Harvey: Dealing with hamstring issue
Harvey (hamstring) was estimated as a non-participant at Wednesday's practice, Chris Tomasson of the Denver Gazette reports.
Since Denver played Monday night, Wednesday was not an official practice. However, Harvey would not have participated if there had been a practice, according to Tomasson. The second-year running back is dealing with a hamstring issue that will be monitored throughout the remainder of the week. This is particularly notable with Denver on a short week. If Harvey is limited or unable to play Sunday against the Jaguars, it would open more opportunities for J.K. Dobbins and Jonah Coleman.
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Michael Pittman WR | PIT
Steelers' Michael Pittman: Limited by foot injury
Pittman (foot) was limited in Wednesday's practice, Steelers reporter Mark Kaboly reports.
Pittman led the team in receiving in Week 1 but is limited to start preparation for Sunday's game against the Patriots due to a foot injury. A limited practice Wednesday is somewhat encouraging when it comes to the severity of the issue. If Pittman is unable to go Sunday, Roman Wilson or Germie Bernard could pick up some of the slack out wide. Pittman has two more practice sessions to get back up to full speed before the team gives an injury status for Sunday.
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Jakobi Meyers WR | JAC
Jaguars' Jakobi Meyers: Limited with thumb issue Wednesday
Meyers (thumb) was limited in Wednesday's practice.
Both Meyers and Brian Thomas (shoulder) were limited in Wednesday's session. Meyers dealt with a thumb injury late in the preseason but was able to give it a go in Week 1, catching two passes for 40 yards and a touchdown. Limited practices may be the norm for Meyers for the time being until his thumb is back to 100 percent, but it certainly didn't stop him from playing well in the opener.
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Brian Thomas Jr. WR | JAC
Jaguars' Brian Thomas: Limited practice Wednesday
Thomas (shoulder) was limited in Wednesday's practice.
This was expected, as coach Liam Coen said Monday that the third-year wideout would be limited this week as he works through a shoulder issue. Coen added that he expects Thomas to be available Week 2, but it will depend on how his shoulder holds up going into the weekend. Of note, fellow wideout Jakobi Meyers (thumb) was also limited Wednesday.